Insulin-Responsive Glucagon Delivery for Prevention of Hypoglycemia.
Insulin-Responsive Glucagon Delivery for Prevention of Hypoglycemia.
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DOI：
10.1002/smll.201603028
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发表时间：
2017-05
期刊：
影响因子：
--
通讯作者：
Gu Z
中科院分区：
文献类型：
--
作者：
Yu J;Zhang Y;Sun W;Kahkoska AR;Wang J;Buse JB;Gu Z
低血糖是指血糖水平异常低的状态，是糖尿病管理中胰岛素和磺脲类药物治疗的急性并发症。日常糖尿病护理期间频繁的胰岛素给药和推注会导致危险的低血糖水平风险增加，这可能导致行为和认知障碍、癫痫发作、昏迷甚至死亡。在这里，我们报告了一种基于微针（MN）阵列贴片的胰岛素响应性胰高血糖素输送方法，用于预防低血糖。通过利用胰岛素适体和靶胰岛素之间的特异性相互作用，响应胰岛素浓度的升高，实现胰高血糖素的控制释放。通过整合无痛 MN 阵列贴片，我们证明这种胰岛素触发的胰高血糖素输送装置能够预防化学诱导的 1 型糖尿病小鼠模型注射高剂量胰岛素后出现低血糖。开发了一种基于微针（MN）阵列贴片的胰岛素响应胰高血糖素输送装置，用于预防低血糖。这种具有新颖触发机制的“智能胰高血糖素贴片”利用高胰岛素血症作为危险信号，可以释放胰高血糖素，降低糖尿病管理过程中发生低血糖的风险，这将深刻改善糖尿病患者的健康和生活质量。
Hypoglycemia, the state of abnormally low blood glucose level, is an acute complication of insulin and sulfonylurea therapy in diabetes management. Frequent insulin dosing and boluses during daily diabetes care leads to an increasing risk of dangerously low glucose levels, which can cause behavioral and cognitive disturbance, seizure, coma, and even death. Here, we report an insulin-responsive glucagon delivery method based on a microneedle (MN)-array patch for the prevention of hypoglycemia. The controlled release of glucagon is achieved in response to elevated insulin concentration by taking advantage of the specific interaction between insulin aptamer and target insulin. Integrating a painless MN-array patch, we demonstrate that this insulin-triggered glucagon delivery device is able to prevent hypoglycemia following a high-dose insulin injection in a chemically-induced type 1 diabetic mouse model. An insulin-responsive glucagon delivery device based on a microneedle (MN)-array patch is developed for prevention of hypoglycemia. Utilizing hyperinsulinemia as a dangerous signal, this “smart glucagon patch” with a novel trigger mechanism can release glucagon to reduce the risk of hypoglycemia during diabetes management, which would profoundly improve the health as well as the quality of life of diabetic patients.
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影响因子：
82.9
作者：
通讯作者：
--
影响因子：
16.2
作者：
Castle JR;Engle JM;El Youssef J;Massoud RG;Yuen KC;Kagan R;Ward WK
通讯作者：
Ward WK
DOI：
10.1039/c1an15407a
发表时间：
2011-10-21
期刊：
The Analyst
影响因子：
--
作者：
Pu Y;Zhu Z;Han D;Liu H;Liu J;Liao J;Zhang K;Tan W
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Tan W
影响因子：
41.2
作者：
DeMuth PC;Min Y;Huang B;Kramer JA;Miller AD;Barouch DH;Hammond PT;Irvine DJ
通讯作者：
Irvine DJ
影响因子：
46.9
作者：
Prausnitz, Mark R.;Langer, Robert
通讯作者：
Langer, Robert