Treadmill training enhances the recovery of normal stepping patterns in spinal cord contused rats.
Treadmill training enhances the recovery of normal stepping patterns in spinal cord contused rats.
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DOI：
10.1016/j.expneurol.2008.11.023
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发表时间：
2009-03
影响因子：
5.3
通讯作者：
de Leon, Ray D.
中科院分区：
文献类型：
--
作者：
Heng, Chad;de Leon, Ray D.
众所周知，跑步机训练可以改善脊髓完全受伤的动物的行走能力。很少有研究探讨跑步机训练是否也能增强不完全脊髓损伤后动物的运动恢复。在本研究中，我们比较了经过训练和未经训练的遭受严重脊髓中部挫伤的大鼠的运动恢复情况。使用机器人设备来训练和测试双足后肢在跑步机上的行走。培训为期8周。该机器人设备支撑大鼠的重量并记录后肢的踝关节运动以进行运动分析。脊髓挫伤后，训练过的和未训练过的大鼠都产生了部分负重后肢行走。未经训练的老鼠在摇摆过程中的拖拽现象比训练过的老鼠更普遍。此外，只有经过训练的大鼠才执行在轨迹形状和运动速度特征方面与正常的步进循环轨迹相似的步进循环轨迹。相比之下，未经训练的老鼠在向前摆动过程中执行的步骤循环包括快速的、类似踢腿的动作。这些发现表明，脊髓挫伤的大鼠在没有跑步机训练的情况下可以产生部分负重步进。研究结果还表明，跑步机训练的作用是恢复大鼠严重不完全脊髓损伤后后肢运动的正常模式。
Treadmill training is known to improve stepping in complete spinal cord injured animals. Few studies have examined whether treadmill training also enhances locomotor recovery in animals following incomplete spinal cord injuries. In the present study, we compared locomotor recovery in trained and untrained rats that received a severe mid-thoracic contusion of the spinal cord. A robotic device was used to train and to test bipedal hindlimb stepping on a treadmill. Training was imposed for 8 weeks. The robotic device supported the weight of the rats and recorded ankle movements in the hindlimbs for movement analyses. Both the trained and untrained rats generated partial weight bearing hindlimb steps after the spinal cord contusion. Dragging during swing was more prevalent in the untrained rats than the trained rats. In addition, only the trained rats performed step cycle trajectories that were similar to normal step cycle trajectories in terms of the trajectory shape and movement velocity characteristics. In contrast, untrained rats executed step cycles that consisted of fast, kick-like movements during forward swing. These findings indicate that spinal cord contused rats can generate partial weight bearing stepping in the absence of treadmill training. The findings also suggest that the effect of treadmill training is to restore normal patterns of hindlimb movements following severe incomplete spinal cord injury in rats.
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影响因子：
2.7
作者：
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通讯作者：
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