Mobilisation of jerboa kidney gene networks during dehydration and opportunistic rehydration.
Mobilisation of jerboa kidney gene networks during dehydration and opportunistic rehydration.
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DOI：
10.1016/j.isci.2023.107574
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发表时间：
2023-09-15
期刊：
影响因子：
5.8
通讯作者：
Murphy, David
中科院分区：
文献类型：
--
作者：
Gillard, Benjamin T.;Amor, Nabil;Iraizoz, Fernando Alvira;Pauza, Audrys G.;Campbell, Colin;Greenwood, Michael P.;Alagaili, Abdulaziz N.;Murphy, David
沙漠动物已经进化出了使它们能够在干燥条件下茁壮成长的系统。专注于肾脏，我们已经调查了转录组的适应，使沙漠啮齿动物，小埃及跳鼠（Jaculus jaculus），承受缺水和机会性补液。对整个肾脏转录组的分析显示，与对照组相比，跳鼠肾脏中有许多差异表达的基因，脱水后有6.4%的基因，再水化后有更多的基因（36.2%）。与复水条件相关的基因包括许多核糖体蛋白编码基因，这表明当有水可用时，协同努力加速蛋白质合成。我们鉴定了在脱水中TGF-β信号传导拮抗剂的增加（例如，GREM2）。我们还描述了多个水通道蛋白和溶质载体转运映射到特定的肾单位段的表达。沙漠适应肾转录组这里提出的是一个宝贵的资源，扩大我们的理解超越了模式生物的调节。沙漠啮齿动物Jaculus jaculus是无水生存的专家肾脏基因表达对脱水和再水化反应的大变化BMP拮抗剂GREM 2在跳鼠肾脏脱水反应中可能很重要许多基因在再水化后发生变化，参与翻译过程动物;环境;暴露;转录组学
Desert animals have evolved systems that enable them to thrive under dry conditions. Focusing on the kidney, we have investigated the transcriptomic adaptations that enable a desert rodent, the Lesser Egyptian Jerboa (Jaculus jaculus), to withstand water deprivation and opportunistic rehydration. Analysis of the whole kidney transcriptome showed many differentially expressed genes in the Jerboa kidney, 6.4% of genes following dehydration and an even greater number (36.2%) following rehydration compared to control. Genes correlated with the rehydration condition included many ribosomal protein coding genes suggesting a concerted effort to accelerate protein synthesis when water is made available. We identify an increase in TGF-beta signaling antagonists in dehydration (e.g., GREM2). We also describe expression of multiple aquaporin and solute carrier transporters mapped to specific nephron segments. The desert adapted renal transcriptome presented here is a valuable resource to expand our understanding of osmoregulation beyond that derived from model organisms. The desert rodent Jaculus jaculus is an expert at surviving without water Large changes in renal gene expression respond to dehydration and rehydration BMP antagonist GREM2 may be important in the Jerboa kidney dehydration response Many genes that change after rehydration are involved in translation processes Animals; Environment; Exposure; Transcriptomics
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影响因子：
4.9
作者：
Glaser, Jason;Hansson, Erik;Wegman, David H.
通讯作者：
Wegman, David H.
DOI：
10.1097/00075197-200209000-00010
发表时间：
2002-09-01
影响因子：
3.1
作者：
Kavouras, SA
通讯作者：
Kavouras, SA
DOI：
10.1016/0300-9629(83)90629-1
发表时间：
1983-01-01
影响因子：
2.3
作者：
ARAD, Z;MARDER, J;EYLATH, U
通讯作者：
EYLATH, U
影响因子：
5.9
作者：
Alvira-Iraizoz F;Gillard BT;Lin P;Paterson A;Pauža AG;Ali MA;Alabsi AH;Burger PA;Hamadi N;Adem A;Murphy D;Greenwood MP
通讯作者：
Greenwood MP
影响因子：
3.3
作者：
Bittner, Noelle K. J.;Mack, Katya L.;Nachman, Michael W.
通讯作者：
Nachman, Michael W.