The plant Mediator complex and its role in jasmonate signaling

The plant Mediator complex and its role in jasmonate signaling
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植物介体复合物及其在茉莉酸信号传导中的作用

DOI:
10.1093/jxb/erz233
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发表时间:
2019-05
影响因子:
6.9
通讯作者:
Li Chuanyou
Li Chuanyou
中科院分区:
生物学1区
文献类型:
--
作者:
Zhai Qingzhe;Li Chuanyou

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介体复合物是一种重要的多亚基转录辅激活因子,在真核生物中高度保守。介体与基因特异性转录因子、RNA聚合酶II转录机制以及参与转录的其他几个因子相互作用,并作为一个整体枢纽来调节转录的各个方面。最近对植物介体复合体的研究已经确定,它在植物发育和适应的各个方面发挥作用。茉莉酸(JA)是一种氧脂衍生的植物激素,调节植物的免疫和发育。碱性螺旋-环-螺旋转录因子MYC 2是JA信号传导的主要调节因子,其协调植物细胞的全基因组转录重编程以协调防御和生长相关过程。本文综述了植物介体复合物在JA信号转导中的作用。我们专注于多功能介体亚基MED 25,它作为茉莉酸信号的转录调控的综合枢纽而出现。
Abstract The Mediator complex is an essential, multisubunit transcriptional coactivator that is highly conserved in eukaryotes. Mediator interacts with gene-specific transcription factors, the RNA polymerase II transcriptional machinery, as well as several other factors involved in transcription, and acts as an integral hub to regulate various aspects of transcription. Recent studies of the plant Mediator complex have established that it functions in diverse aspects of plant development and fitness. Jasmonate (JA) is an oxylipin-derived plant hormone that regulates plant immunity and development. The basic helix–loop–helix transcription factor MYC2, which is a master regulator of JA signaling, orchestrates genome-wide transcriptional reprogramming of plant cells to coordinate defense- and growth-related processes. Here, we review the function of the plant Mediator complex in regulating JA signaling. We focus on the multifunctional Mediator subunit MED25, which emerges as an integrative hub for the transcriptional regulation of jasmonate signaling.
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