Dopamine D1 sensitivity in the prefrontal cortex predicts general cognitive abilities and is modulated by working memory training.
Dopamine D1 sensitivity in the prefrontal cortex predicts general cognitive abilities and is modulated by working memory training.
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DOI：
10.1101/lm.031971.113
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发表时间：
2013-10-15
期刊：
影响因子：
--
通讯作者：
Matzel LD
中科院分区：
文献类型：
--
作者：
Wass C;Pizzo A;Sauce B;Kawasumi Y;Sturzoiu T;Ree F;Otto T;Matzel LD
差异的共同来源（即，一般智力（“一般智力”）是个体在各种认知能力测试中表现的基础，有证据表明，工作记忆的加工效能可能是共同差异的一个来源。工作记忆的一个组成部分，选择性注意力，已经被报道与一般智力共同变化，前额叶皮层中的多巴胺D1信号可以调节注意力能力。基于他们在五个不同的学习测试中的综合表现，我们在这里描述了CD-1远交系小鼠的一般认知能力（GCA）。在响应D1激动剂（SKF 82958，1毫克/公斤），然后，我们评估GCA和激活的D1受体（D1 R）-在内侧前额叶皮层，无颗粒岛叶皮层，和背内侧纹状体的边缘区含神经元之间的关系。与低GCA动物相比，高GCA动物的前边缘皮质（但非无颗粒岛叶皮质或背内侧纹状体）中含D1 R神经元的激活增加（通过对D1激动剂的c-Fos激活进行定量）。然而，蛋白质印迹分析显示，高和低GCA的动物之间的前边缘皮层的D1 R的密度没有差异。最后，我们观察到工作记忆训练促进了动物GCA的增加，并增强了D1 R介导的前边缘皮层神经元激活。这些结果表明，边缘前皮层D1 Rs的敏感性（而不是密度）可能既调节GCA，也是工作记忆训练的目标。
A common source of variance (i.e., “general intelligence”) underlies an individual's performance across diverse tests of cognitive ability, and evidence indicates that the processing efficacy of working memory may serve as one such source of common variance. One component of working memory, selective attention, has been reported to co-vary with general intelligence, and dopamine D1 signaling in prefrontal cortex can modulate attentional abilities. Based on their aggregate performance across five diverse tests of learning, here we characterized the general cognitive ability (GCA) of CD-1 outbred mice. In response to a D1 agonist (SKF82958, 1 mg/kg), we then assessed the relationship between GCA and activation of D1 receptor (D1R)-containing neurons in the prelimbic region of the medial prefrontal cortex, the agranular insular cortex, and the dorsomedial striatum. Increased activation of D1R-containing neurons in the prelimbic cortex (but not the agranular insular cortex or dorsomedial striatum) was observed in animals of high GCA relative to those of low GCA (quantified by c-Fos activation in response to the D1 agonist). However, a Western blot analysis revealed no differences in the density of D1Rs in the prelimbic cortex between animals of high and low GCA. Last, it was observed that working memory training promoted an increase in animals’ GCA and enhanced D1R-mediated neuronal activation in the prelimbic cortex. These results suggest that the sensitivity (but not density) of D1Rs in the prelimbic cortex may both regulate GCA and be a target for working memory training.
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影响因子：
5.3
作者：
Aalto, S;Brück, A;Rinne, JO
通讯作者：
Rinne, JO
影响因子：
64.8
作者：
Deary, Ian J.;Yang, Jian;Visscher, Peter M.
通讯作者：
Visscher, Peter M.
DOI：
10.1016/j.cortex.2012.05.022
发表时间：
2013-05
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
Barbey AK;Koenigs M;Grafman J
通讯作者：
Grafman J
影响因子：
3.4
作者：
Colom, Roberto;Jung, Rex E.;Haier, Richard J.
通讯作者：
Haier, Richard J.
影响因子：
2.5
作者：
Costa, R. M.;Gutierrez, R.;Simon, S. A.
通讯作者：
Simon, S. A.