Engineering exosomes for targeted drug delivery.
Engineering exosomes for targeted drug delivery.
复制标题
工程化外泌体用于靶向药物递送
作者：
Liang Y;Duan L;Lu J;Xia J
外泌体是细胞来源的纳米囊泡，其参与物质的细胞间运输。小分子或核酸药物等治疗药物可以掺入外泌体中，然后递送至特定类型的细胞或组织，实现靶向药物递送。靶向递送增加治疗剂的局部浓度并使副作用最小化。在这里，我们提出了一个详细的审查外泌体工程通过遗传和化学方法的靶向药物输送。虽然仍处于起步阶段，但外泌体介导的药物递送具有低毒性，低免疫原性和高工程性，并有望用于广泛疾病的无细胞疗法。
Exosomes are cell-derived nanovesicles that are involved in the intercellular transportation of materials. Therapeutics, such as small molecules or nucleic acid drugs, can be incorporated into exosomes and then delivered to specific types of cells or tissues to realize targeted drug delivery. Targeted delivery increases the local concentration of therapeutics and minimizes side effects. Here, we present a detailed review of exosomes engineering through genetic and chemical methods for targeted drug delivery. Although still in its infancy, exosome-mediated drug delivery boasts low toxicity, low immunogenicity, and high engineerability, and holds promise for cell-free therapies for a wide range of diseases.
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影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
影响因子：
7.3
作者：
Andreu Z;Yáñez-Mó M
通讯作者：
Yáñez-Mó M
影响因子：
12.4
作者：
Bellavia D;Raimondo S;Calabrese G;Forte S;Cristaldi M;Patinella A;Memeo L;Manno M;Raccosta S;Diana P;Cirrincione G;Giavaresi G;Monteleone F;Fontana S;De Leo G;Alessandro R
通讯作者：
Alessandro R
DOI：
10.1016/j.jconrel.2015.07.030
发表时间：
2015-12-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Batrakova EV;Kim MS
通讯作者：
Kim MS
DOI：
10.1126/science.aau6977
发表时间：
2020-02-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kalluri R;LeBleu VS
通讯作者：
LeBleu VS