Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy.
Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy.
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DOI：
10.1038/s41598-021-03555-7
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发表时间：
2021-12-20
影响因子：
4.6
通讯作者：
Worrell GA
中科院分区：
文献类型：
--
作者：
Gregg NM;Sladky V;Nejedly P;Mivalt F;Kim I;Balzekas I;Sturges BK;Crowe C;Patterson EE;Van Gompel JJ;Lundstrom BN;Leyde K;Denison TJ;Brinkmann BH;Kremen V;Worrell GA
慢性脑记录表明，癫痫发作的风险并不是统一的，而是相对于每日(昼夜节律)和多天(多日)周期有系统地变化。在这里，一名患有自然癫痫的人和七只狗使用新型植入式传感和刺激设备进行了连续的颅内脑电(中位数为298天)。两只宠物狗和人类受试者同时接受了几个月的丘脑深部脑刺激(DBS)。所有受试者的发作间期癫痫样棘波(IES)都有昼夜节律和多天周期。在8名受试者中，分别有5名和7名受试者的癫痫相锁定于昼夜节律和多天IES周期。丘脑DBS改变了昼夜节律(所有3个受试者)和多天(分析仅限于人类参与者)IES周期。DBS在人类受试者中修改了癫痫丛集和昼夜节律相位锁定。大脑兴奋性和癫痫风险的多尺度循环是人类和犬癫痫的特征，可以通过丘脑DBS改变。
Chronic brain recordings suggest that seizure risk is not uniform, but rather varies systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human and seven dogs with naturally occurring epilepsy had continuous intracranial EEG (median 298 days) using novel implantable sensing and stimulation devices. Two pet dogs and the human subject received concurrent thalamic deep brain stimulation (DBS) over multiple months. All subjects had circadian and multiday cycles in the rate of interictal epileptiform spikes (IES). There was seizure phase locking to circadian and multiday IES cycles in five and seven out of eight subjects, respectively. Thalamic DBS modified circadian (all 3 subjects) and multiday (analysis limited to the human participant) IES cycles. DBS modified seizure clustering and circadian phase locking in the human subject. Multiscale cycles in brain excitability and seizure risk are features of human and canine epilepsy and are modifiable by thalamic DBS.
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影响因子：
9.9
作者：
Caciagli L;Allen LA;He X;Trimmel K;Vos SB;Centeno M;Galovic M;Sidhu MK;Thompson PJ;Bassett DS;Winston GP;Duncan JS;Koepp MJ;Sperling MR
通讯作者：
Sperling MR
影响因子：
25
作者：
Chang, Wei-Chih;Kudlacek, Jan;Jiruska, Premysl
通讯作者：
Jiruska, Premysl
影响因子：
14.5
作者：
Guye, Maxime;Regis, Jean;Bartolomei, Fabrice
通讯作者：
Bartolomei, Fabrice
影响因子：
5.6
作者：
Fisher, Robert;Salanova, Vicenta;Graves, Nina
通讯作者：
Graves, Nina
影响因子：
5.6
作者：
Gregg, Nicholas M.;Marks, Victoria S.;Worrell, Gregory A.
通讯作者：
Worrell, Gregory A.