The relationship between low pH in intervertebral discs and low back pain: a systematic review.
The relationship between low pH in intervertebral discs and low back pain: a systematic review.
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椎间盘低 pH 值与腰痛之间的关系：系统评价。
DOI：
10.5114/aoms.2012.32401
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发表时间：
2012-12-20
期刊：
影响因子：
--
通讯作者：
Chen QX
中科院分区：
文献类型：
--
作者：
Liang CZ;Li H;Tao YQ;Zhou XP;Yang ZR;Li FC;Chen QX
系统综述椎间盘内低pH值与腰痛的关系。电子数据库（PubMed、ISI Web of Science、科克伦图书馆、CINAHL、AMED和中国国家知识基础设施）检索和手工检索会议记录。两位作者独立评价了方法学质量，并根据标准标准提取了相关数据。然后对最终检索到的文献中使用的实验方法和样本进行评估。我们首先检索了136篇关于疼痛和pH的文章，其中只有16篇主要是关于腰痛和pH的。最后，7篇文章符合我们的预期，关注pH引起的腰痛的发病机制。在这7篇研究中，作者对低pH引起的腰痛的发病机制有三种解释。首先，由乳酸盐引起的低pH刺激肌肉并增加肌肉张力，这导致腰痛。其次，低pH值刺激神经根并产生疼痛感。第三，低pH改变基质代谢，导致神经元死亡和腰痛。在这篇系统性综述中，我们提出了一个新的假设，即腰痛可能是由低pH值的基础上，以前的文献。需要进一步的实验研究来验证我们的假设。这一假说将促进我们对下腰痛发病机制的理解，并为下腰痛的诊断和治疗提供新的方法。
To systematically review the relationship between low pH in intervertebral discs and low back pain. Electronic database (PubMed, ISI Web of Science, Cochrane Library, CINAHL, AMED, and China National Knowledge Infrastructure) searches and hand searching of conference proceedings were conducted. Two authors independently evaluated the methodological quality and abstracted relevant data according to standard criteria. Then the experimental methods and samples employed in the finally retrieved articles were assessed. We first retrieved 136 articles regarding pain and pH, and only 16 of them were mainly about low back pain and pH. Finally, 7 articles met our expectation to focus on the pathogenesis of low back pain caused by pH. In these 7 studies the authors held three opinions to explain the pathogenesis of low back pain in relation to low pH. First, low pH caused by lactate stimulates the muscle and increases the muscle tension, which causes low back pain. Second, low pH stimulates the nerve roots and produces the feeling of pain. Third, low pH changes the matrix metabolism, leading to neuronal death and low back pain. In this systematic review we propose a new hypothesis that low back pain may be caused by low pH based on the previous literature. Further experimental studies are necessary to verify our hypothesis. This hypothesis will promote our understanding of the pathogenesis of low back pain and the development of novel diagnostic and therapeutic approaches for low back pain.
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影响因子：
2.8
作者：
Ishihara, H;Urban, JPG
通讯作者：
Urban, JPG
影响因子：
3.1
作者：
DePalma, Michael J.;Ketchum, Jessica M.;Saullo, Thomas
通讯作者：
Saullo, Thomas
影响因子：
3
作者：
KIRKALDY-WILLIS W H;WEDGE J H;REILLY J
通讯作者：
REILLY J
DOI：
10.1097/00002517-199212000-00002
发表时间：
1992-12-01
期刊：
JOURNAL OF SPINAL DISORDERS
影响因子：
--
作者：
PANJABI, MM
通讯作者：
PANJABI, MM
DOI：
10.5114/aoms.2010.14477
发表时间：
2010-08-30
期刊：
Archives of medical science : AMS
影响因子：
--
作者：
Karabekir HS;Yildizhan A;Atar EK;Yaycioglu S;Gocmen-Mas N;Yazici C
通讯作者：
Yazici C