Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer.
Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer.
复制标题
植物源性天然产物治疗宫颈癌的潜在机制
DOI：
10.3390/biom11101539
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发表时间：
2021-10-18
期刊：
影响因子：
5.5
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
He M;Xia L;Li J
宫颈癌是全球第二大常见妇科恶性肿瘤；由于发病率和死亡率高，它严重危害妇女的健康。常规治疗容易产生耐药、复发和转移。因此，迫切需要开发高效、低副作用的新药来防治宫颈癌。近年来，植物源性天然产物被评价为具有优先杀伤肿瘤细胞而无严重不良反应的潜在抗癌药物。越来越多的研究表明，天然产物可通过抑制肿瘤细胞增殖、诱导细胞凋亡、抑制血管生成和端粒酶活性、增强免疫力和逆转多药耐药等多种机制实现实际的抗宫颈癌作用。本文综述了植物源性天然产物对宫颈癌的治疗作用及机制，为开发高效、低副作用的抗宫颈癌药物提供参考。
Cervical cancer is the second most common gynecological malignancy globally; it seriously endangers women’s health because of its high morbidity and mortality. Conventional treatments are prone to drug resistance, recurrence and metastasis. Therefore, there is an urgent need to develop new drugs with high efficacy and low side effects to prevent and treat cervical cancer. In recent years, plant-derived natural products have been evaluated as potential anticancer drugs that preferentially kill tumor cells without severe adverse effects. A growing number of studies have shown that natural products can achieve practical anti-cervical-cancer effects through multiple mechanisms, including inhibition of tumor-cell proliferation, induction of apoptosis, suppression of angiogenesis and telomerase activity, enhancement of immunity and reversal of multidrug resistance. This paper reviews the therapeutic effects and mechanisms of plant-derived natural products on cervical cancer and provides references for developing anti-cervical-cancer drugs with high efficacy and low side effects.
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影响因子：
51.1
作者：
de Sanjose, Silvia;Quint, Wim G. V.;Xavier Bosch, F.
通讯作者：
Xavier Bosch, F.
影响因子：
4.3
作者：
Al-Hazzani, Amal A.;Alshatwi, Ali A.
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影响因子：
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通讯作者：
Limtrakul, P
影响因子：
3.6
作者：
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通讯作者：
Chen, Pei-Ni
影响因子：
5.6
作者：
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通讯作者：
Adelson DL