Amide signal intensities may be reduced in the motor cortex and the corticospinal tract of ALS patients
Amide signal intensities may be reduced in the motor cortex and the corticospinal tract of ALS patients
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ALS 患者运动皮层和皮质脊髓束的酰胺信号强度可能降低
DOI：
10.1007/s00330-020-07243-4
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Alan H Wilman
中科院分区：
文献类型：
--
作者：
Zhuozhi Dai;Sanjay Kalra;Dennell Mah;Peter Seres;Hongfu Sun;Renhua Wu;Alan H Wilman
目的应用定量酰胺质子转移成像(APT)和多参数磁共振成像技术，评价ALS患者和健康对照组血浆中酰胺浓度的变化，并探讨其与临床评分的相关性。方法选择ALS患者和健康对照组各16例，采用多模式磁共振成像，包括APT和扩散成像。用Lorentz拟合法对酰胺效应进行量化。采用修订的肌萎缩侧索硬化症功能评定量表(ALSFRS-R)评定临床残疾，并评价其与影像特征的相关性。结果发现肌萎缩侧索硬化症患者运动皮质与脑内其他灰质区域的酰胺峰有显著差异(p<； 0.001)。与对照组相比，肌萎缩侧索硬化症患者运动皮质(p<； 0.001)和皮质脊髓束(p= 0.046)的酰胺信号强度显著降低，而常规成像方法未发现异常。酰胺与ALSFRS-R评分无显著相关性。结论肌萎缩侧索硬化症患者运动皮质和皮质脊髓束的酰胺信号强度发生了变化。重点·神经退行性疾病肌萎缩侧索硬化症(ALS)缺乏客观的影像诊断和评估指标。·酰胺质子转移成像分析揭示了ALS患者运动皮质和皮质脊髓束常规磁共振成像无法显示的改变。
ObjectivesThe aim of the study is to assess amide concentration changes in ALS patients compared with healthy controls by using quantitative amide proton transfer (APT) and multiparameter magnetic resonance imaging, and testing its correlation with clinical scores.MethodsSixteen ALS patients and sixteen healthy controls were recruited as part of the Canadian ALS Neuroimaging Consortium, and multimodal magnetic resonance imaging was performed at 3 T, including APT and diffusion imaging. Lorentz fitting was used to quantify the amide effect. Clinical disability was evaluated using the revised ALS functional rating scale (ALSFRS-R), and its correlation with image characteristics was assessed. The diagnostic performance of different imaging parameters was evaluated with receiver operating characteristic analysis.ResultsOur results showed that the amide peak was significantly different between the motor cortex and other gray matter territories within the brain of ALS patients (p< 0.001). Compared with controls, amide signal intensities in ALS were significantly reduced in the motor cortex (p< 0.001) and corticospinal tract (p= 0.046), while abnormalities were not detected using routine imaging methods. There was no significant correlation between amide and ALSFRS-R score. The diagnostic accuracy of the amide peak was superior to that of diffusion imaging.ConclusionsThis study demonstrated changes of amide signal intensities in the motor cortex and corticospinal tract of ALS patients.Key Points• The neurodegenerative disease amyotrophic lateral sclerosis (ALS) has a lack of objective imaging indicators for diagnosis and assessment.• Analysis of amide proton transfer imaging revealed changes in the motor cortex and corticospinal tract of ALS patients that were not visible on standard magnetic resonance imaging.• The diagnostic accuracy of the amide peak was superior to that of diffusion imaging.
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影响因子：
3.4
作者：
Lin G;Zhuang C;Shen Z;Xiao G;Chen Y;Shen Y;Zong X;Wu R
通讯作者：
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来自Z频谱拟合的2ppm（CEST@2ppm）处的CEST信号与脑肿瘤中的肌酸分布相关。
影响因子：
2.9
作者：
Cai, Kejia;Singh, Anup;Poptani, Harish;Li, Weiguo;Yang, Shaolin;Lu, Yang;Hariharan, Hari;Zhou, Xiaohong J.;Reddy, Ravinder
通讯作者：
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DOI：
10.1016/s0140-6736(22)01272-7
发表时间：
2022-10-15
期刊：
Lancet (London, England)
影响因子：
--
作者：
通讯作者：
--
影响因子：
64.8
作者：
Brian M. Owens
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DOI：
10.1021/acschemneuro.8b00482
发表时间：
--
期刊：
ACS Chem Neurosci [Epub ahead of print]
影响因子：
--
作者：
Zhuang Z;Shen Z;Chen Y;Dai Z;Zhang X;Mao Y;Zhang B;Zeng H;Chen P;Wu R
通讯作者：
Wu R