What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders.
What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders.
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DOI：
10.1007/s12035-011-8165-5
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发表时间：
2011-10
影响因子：
5.1
通讯作者：
Zeisel, Steven H.
中科院分区：
文献类型：
--
作者：
Zeisel, Steven H.
胎儿接触酒精的后果是非常多样的，可能涉及的分子机制必须能够解释为什么这么多的发育过程会出错。如果给怀孕的大鼠喂食酒精，它们的幼崽就会出现胎儿酒精谱系障碍（FASD）的异常特征，但如果给这些大鼠喂食胆碱，乙醇对幼崽的影响就会减弱。胆碱是人体必需的营养物质，是重要的甲基供体。酒精会干扰胆碱和其他甲基供体的代谢。妊娠期胆碱的可用性直接影响DNA和组蛋白上的表观遗传标记，并改变正常神经和内皮祖细胞增殖所需的基因表达。母鼠低胆碱饮食改变了小鼠海马体的发育，并降低了终生记忆。低胆碱饮食的妇女生下患有神经管或面瘫出生缺陷的婴儿的风险增加。因此，胆碱的不同作用可能影响FASD的表达，对胆碱的研究可能有助于揭示FASD的潜在分子机制。
The consequences of fetal exposure to alcohol are very diverse and the likely molecular mechanisms involved must be able to explain how so many developmental processes could go awry. If pregnant rat dams are fed alcohol, their pups develop abnormalities characteristic of fetal alcohol spectrum disorders (FASD), but if these rat dams were also treated with choline, the effects from ethanol were attenuated in their pups. Choline is an essential nutrient in humans, and is an important methyl group donor. Alcohol exposure disturbs the metabolism of choline and other methyl donors. Availability of choline during gestation directly influences epigenetic marks on DNA and histones, and alters gene expression needed for normal neural and endothelial progenitor cell proliferation. Maternal diets low in choline alter development of the mouse hippocampus, and decrement memory for life. Women eating low-choline diets have an increased risk of having an infant with a neural tube or or ofacial cleft birth defect. Thus, the varied effects of choline could affect the expression of FASD, and studies on choline might shed some light on the underlying molecular mechanisms responsible for FASD.
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影响因子：
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