Nanocomposites with spatially separated functionalities for combined imaging and magnetolytic therapy.

Nanocomposites with spatially separated functionalities for combined imaging and magnetolytic therapy.
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DOI:
10.1021/ja102489q
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发表时间:
2010-06-02
影响因子:
15
通讯作者:
Gao X
Gao X
中科院分区:
化学1区
文献类型:
--
作者:
Hu SH;Gao X

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具有高度集成功能的紧凑纳米结构在药物递送、多模态成像和电子设备方面具有相当大的当前兴趣。然而,一个关键的挑战是如何将联合收割机各个组件组合在一起,而不干扰或牺牲其原有的电子和光学特性。在这里,我们展示了一类新的纳米复合材料与空间分离的功能。我们进一步展示了磁场调制成像和这种技术在癌细胞治疗中的创新应用,基于对细胞膜的磁控机械损伤的溶磁治疗。
Compact nanostructures with highly integrated functionalities are of considerable current interest to drug delivery, multimodality imaging, and electronic devices. A key challenge, however, is how to combine individual components together without interfering or sacrificing their original electronic and optical properties. Here, we demonstrate a new class of nanocomposites with spatially separated functionalities. We further demonstrate magnetic field modulated imaging and an innovative application of this technology in cancer cell treatment, magnetolytic therapy, based on magnetically controlled mechanical damage to cell membranes.
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