Engineered nanoparticles induce cell apoptosis: potential for cancer therapy.
Engineered nanoparticles induce cell apoptosis: potential for cancer therapy.
复制标题
工程纳米颗粒诱导细胞凋亡：癌症治疗的潜力
DOI：
10.18632/oncotarget.8553
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发表时间：
2016-06-28
期刊：
影响因子：
--
通讯作者：
Yang WX
中科院分区：
文献类型：
--
作者：
Ma DD;Yang WX
近年来，工程纳米颗粒（ENPs）在工业、商品、生物和医学领域得到了广泛的应用。对人类健康的许多相关威胁的可能性已得到强调。粒径不大于100 nm的ENPs能够进入人体并在脑、肝、肺、睾丸等器官中蓄积，并引起毒性作用。许多文献研究了ENP对不同器官细胞的影响，并注意到相关的细胞凋亡。了解ENP诱导细胞凋亡的途径可能有助于设计有效的癌症靶向ENP药物。这样的ENP可以对癌细胞凋亡具有直接作用，或者可以用作药物递送剂。ENPs的特征，如大小、形状、形式、电荷和表面修饰都被认为在决定其在靶细胞中的毒性方面起作用。这些特征的特定修饰可用于降低ENP生物活性，从而减轻不需要的细胞毒性，而不影响预期功能。这提供了设计对非靶细胞具有最小毒性的ENP的机会。
Engineered nanoparticles (ENPs) have been widely applied in industry, commodities, biology and medicine recently. The potential for many related threats to human health has been highlighted. ENPs with their sizes no larger than 100 nm are able to enter the human body and accumulate in organs such as brain, liver, lung, testes, etc, and cause toxic effects. Many references have studied ENP effects on the cells of different organs with related cell apoptosis noted. Understanding such pathways towards ENP induced apoptosis may aid in the design of effective cancer targeting ENP drugs. Such ENPs can either have a direct effect towards cancer cell apoptosis or can be used as drug delivery agents. Characteristics of ENPs, such as sizes, shape, forms, charges and surface modifications are all seen to play a role in determining their toxicity in target cells. Specific modifications of such characteristics can be applied to reduce ENP bioactivity and thus alleviate unwanted cytotoxicity, without affecting the intended function. This provides an opportunity to design ENPs with minimum toxicity to non-targeted cells.
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作者：
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