Surgery improves the prognosis of colon mucinous adenocarcinoma with liver metastases: a SEER-based study.
Surgery improves the prognosis of colon mucinous adenocarcinoma with liver metastases: a SEER-based study.
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手术可改善结肠粘液腺癌肝转移的预后：一项基于 SEER 的研究
DOI：
10.1186/s12885-020-07400-4
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发表时间：
2020-09-23
期刊：
影响因子：
3.8
通讯作者：
Xiao S
中科院分区：
文献类型：
--
作者：
Huang J;Chen G;Liu H;Zhang Y;Tang R;Huang Q;Fu K;Peng X;Xiao S
粘液腺癌(MC)是结肠癌(CC)的第二大常见病理类型。结肠癌肝转移(CLM)是一种常见且致命的肿瘤，对于CLM患者来说，彻底切除原发肿瘤和转移瘤将是有益的。然而，手术治疗MC合并肝转移(M-CLM)的作用仍未达成共识。方法检索2010年至2013年在监测、流行病学和结局数据库(SEER)中诊断为M-CLM或经典型腺癌合并肝转移(A-CLM)的患者。结果与A-CLM组相比，M-CLM组肿瘤体积更大，右半结肠定位更多，PT和PN分期更高，女性患者更多，淋巴结回收和阳性淋巴结更多，手术所占比例更高。接受任何类型手术的M-CLM患者的OS和CS明显好于未接受任何手术的患者，但逊于接受手术的A-CLM患者。同时，未接受任何手术的M-CLM和A-CLM患者的OS和CS相似。与半结肠切除相比，部分结肠切除可使M-CLM的OS和CS接近或更好，而手术是M-CLM长期生存的独立保护因素。结论M-CLM具有与A-CLM不同的临床病理特征，手术可提高生存率，是M-CLM独立的有利预后因素。此外，根据本研究的结果，部分结肠切除术可能是治疗M-CLM的非劣势选择。
BackgroundMucinous adenocarcinoma (MC) is the second most common pathological type of colon carcinoma (CC). Colon cancer liver metastases (CLMs) are common and lethal, and complete resection of the primary tumour and metastases for CLM patients would be beneficial. However, there is still no consensus on the role of surgery for MC with liver metastases (M-CLM).MethodsPatients diagnosed with M-CLM or classical adenocarcinoma with CLM (A-CLM) from 2010 to 2013 in the Surveillance, Epidemiology, and End Results (SEER) database were retrieved. The clinicopathological features and overall survival (OS) and cancer-specific survival (CSS) data were compared and analysed.ResultsThe results showed that the M-CLM group had a larger tumour size, more right colon localizations, higher pT and pN stages, more female patients, and more retrieved and positive lymph nodes and accounted for a higher proportion of surgeries than the A-CLM group. The OS and CSS of M-CLM patients who underwent any type of surgery were significantly better than those of patients who did not undergo any surgery, but poorer than those of A-CLM patients who underwent surgery. Meanwhile, the OS and CSS of M-CLM and A-CLM patients who did not undergo any surgery were comparable. Compared with hemicolectomy, partial colectomy led to similar or better OS and CSS for M-CLM, and surgery was an independent protective factor for long-term survival in M-CLM.ConclusionsM-CLM had distinct clinicopathological characteristics from A-CLM, and surgery could improve the survival and is an independent favourable prognostic factor for M-CLM. In addition, partial colectomy might be a non-inferiority choice as hemicolectomy for M-CLM according to the results from this study.
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影响因子：
5.8
作者：
Damjanov, Nevena;Weiss, Jared;Haller, Daniel G.
通讯作者：
Haller, Daniel G.
影响因子：
3.7
作者：
Hyngstrom JR;Hu CY;Xing Y;You YN;Feig BW;Skibber JM;Rodriguez-Bigas MA;Cormier JN;Chang GJ
通讯作者：
Chang GJ
影响因子：
9
作者：
Nitsche U;Zimmermann A;Späth C;Müller T;Maak M;Schuster T;Slotta-Huspenina J;Käser SA;Michalski CW;Janssen KP;Friess H;Rosenberg R;Bader FG
通讯作者：
Bader FG
影响因子：
3.9
作者：
Mahmoud, Najjia;Dunn, Kelli Bullard
通讯作者：
Dunn, Kelli Bullard
影响因子：
8.8
作者：
Catalano, V.;Loupakis, F.;Graziano, F.;Torresi, U.;Bisonni, R.;Mari, D.;Fornaro, L.;Baldelli, A. M.;Giordani, P.;Rossi, D.;Alessandroni, P.;Giustini, L.;Silva, R. R.;Falcone, A.;D'Emidio, S.;Fedeli, S. L.
通讯作者：
Fedeli, S. L.