HMGB1, an alarmin promoting HIV dissemination and latency in dendritic cells.
HMGB1, an alarmin promoting HIV dissemination and latency in dendritic cells.
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DOI：
10.1038/cdd.2011.134
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发表时间：
2012-01
影响因子：
12.4
通讯作者：
中科院分区：
文献类型：
--
作者：
树突状细胞（DC）通过转运抗原并迁移至淋巴组织以启动T细胞应答来启动免疫应答。树突状细胞位于粘膜表面，参与人类免疫缺陷病毒（HIV）的传播，它们可能是HIV-1感染的最早靶点之一。DC在病毒传播和扩散中具有重要作用，并且HIV-1已经进化出不同的策略来逃避DC抗病毒活性。高迁移率族蛋白1（HMGB 1）是一种DNA结合核蛋白，可作为警报素，一种危险信号，提醒先天免疫系统启动宿主防御。它是典型的损伤相关分子模式分子，并且可以由先天性细胞（包括DC和自然杀伤（NK）细胞）分泌。DC的命运依赖于与NK细胞的同源相互作用，这涉及在NK-DC突触处表达的HMGB 1。HMGB 1是DC成熟、向淋巴组织迁移和幼稚T细胞功能性1型极化所必需的。本文综述了HIV对HMGB 1和DC相互作用的影响，重点介绍了HMGB 1依赖的病毒在DC中传播和持续存在的机制，并讨论了其对抗病毒天然免疫、免疫激活和HIV发病机制的影响。
Dendritic cells (DCs) initiate immune responses by transporting antigens and migrating to lymphoid tissues to initiate T-cell responses. DCs are located in the mucosal surfaces that are involved in human immunodeficiency virus (HIV) transmission and they are probably among the earliest targets of HIV-1 infection. DCs have an important role in viral transmission and dissemination, and HIV-1 has evolved different strategies to evade DC antiviral activity. High mobility group box 1 (HMGB1) is a DNA-binding nuclear protein that can act as an alarmin, a danger signal to alert the innate immune system for the initiation of host defense. It is the prototypic damage-associated molecular pattern molecule, and it can be secreted by innate cells, including DCs and natural killer (NK) cells. The fate of DCs is dependent on a cognate interaction with NK cells, which involves HMGB1 expressed at NK–DC synapse. HMGB1 is essential for DC maturation, migration to lymphoid tissues and functional type-1 polarization of naïve T cells. This review highlights the latest advances in our understanding of the impact of HIV on the interactions between HMGB1 and DCs, focusing on the mechanisms of HMGB1-dependent viral dissemination and persistence in DCs, and discussing the consequences on antiviral innate immunity, immune activation and HIV pathogenesis.
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影响因子：
30.5
作者：
Andoniou, CE;van Dommelen, SLH;Degli-Esposti, MA
通讯作者：
Degli-Esposti, MA
影响因子：
82.9
作者：
Fernandez, NC;Lozier, A;Zitvogel, L
通讯作者：
Zitvogel, L
影响因子：
3.8
作者：
Barqasho, Babilonia;Nowak, Piotr;Sonnerborg, Anders
通讯作者：
Sonnerborg, Anders
DOI：
10.1126/science.1168988
发表时间：
2009-03-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Chen GY;Tang J;Zheng P;Liu Y
通讯作者：
Liu Y
影响因子：
3.7
作者：
Hoppe, George;Talcott, Katherine E.;Sears, Jonathan E.
通讯作者：
Sears, Jonathan E.