Lung microstructure in adolescent idiopathic scoliosis before and after posterior spinal fusion.
Lung microstructure in adolescent idiopathic scoliosis before and after posterior spinal fusion.
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DOI：
10.1371/journal.pone.0240265
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Varisco BM
中科院分区：
文献类型：
--
作者：
Thomen RP;Woods JC;Sturm PF;Jain V;Walkup LL;Higano NS;Quirk JD;Varisco BM
青少年特发性脊柱侧凸（AIS）与呼吸质量下降和隔膜功能受损有关。最近的超极化氦（HHe） MRI研究显示，肺泡形成持续整个青春期，并且已知机械力会影响肺泡形成。因此，我们假设与没有AIS的青少年相比，AIS患者的肺泡大小、肺泡数量或肺泡间隔尺寸会发生改变，而后路脊柱融合术（PSF）可能会逆转这些差异。我们进行了一项前瞻性观察试验，使用HHe MRI来检测对照组和AIS受试者在基线和一年内肺泡微结构的变化。在获得受试者法定监护人的书面知情同意和受试者同意后，我们对14名AIS患者和16名8-21岁的对照组进行了he和质子MRI检查。对照组的平均年龄（12.9岁）明显小于AIS组（14.9岁，p = 0.003）。在基线时，AIS患者与对照组或AIS患者的凹肺（压缩肺）与凸肺（扩张肺）之间的肺泡大小、数量或肺泡导管形态测量无显著差异。在PSF后1年，AIS受试者在原来的凸肺中肺泡密度增加（p = 0.05），可能反映了胸廓解剖结构的变化，但肺微观结构没有其他显著变化。肺泡大小随时间的建模显示，在psf前后，对照组和AIS受试者的左右肺肺泡生长速率相似。虽然这项研究的年龄匹配不佳，但我们没有发现AIS或PSF影响肺组织结构的证据。试验注册：临床试验注册号NCT03539770。
Adolescent idiopathic scoliosis (AIS) is associated with decreased respiratory quality of life and impaired diaphragm function. Recent hyperpolarized helium (HHe) MRI studies show alveolarization continues throughout adolescence, and mechanical forces are known to impact alveolarization. We therefore hypothesized that patients with AIS would have alterations in alveolar size, alveolar number, or alveolar septal dimensions compared to adolescents without AIS, and that posterior spinal fusion (PSF) might reverse these differences. We conducted a prospective observational trial using HHe MRI to test for changes in alveolar microstructure in control and AIS subjects at baseline and one year. After obtaining written informed consent from subjects’ legal guardians and assent from the subjects, we performed HHe and proton MRI in 14 AIS and 16 control subjects aged 8–21 years. The mean age of control subjects (12.9 years) was significantly less than AIS (14.9 years, p = 0.003). At baseline, there were no significant differences in alveolar size, number, or alveolar duct morphometry between AIS and control subjects or between the concave (compressed) and convex (expanded) lungs of AIS subjects. At one year after PSF AIS subjects had an increase in alveolar density in the formerly convex lung (p = 0.05), likely reflecting a change in thoracic anatomy, but there were no other significant changes in lung microstructure. Modeling of alveolar size over time demonstrated similar rates of alveolar growth in control and AIS subjects in both right and left lungs pre- and post-PSF. Although this study suffered from poor age-matching, we found no evidence that AIS or PSF impacts lung microstructure. Trial registration: Clinical trial registration number NCT03539770.
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影响因子：
2.2
作者：
Sukstanskii, A. L.;Yablonskiy, D. A.
通讯作者：
Yablonskiy, D. A.
影响因子：
3.3
作者：
Flors, Lucia;Mugler, John P., III;Altes, Talissa A.
通讯作者：
Altes, Talissa A.
DOI：
10.1164/rccm.201107-1348oc
发表时间：
2012-01-15
影响因子：
24.7
作者：
Narayanan, Manjith;Owers-Bradley, John;Silverman, Michael
通讯作者：
Silverman, Michael
DOI：
10.1164/rccm.201802-0274oc
发表时间：
2018-12-15
影响因子：
24.7
作者：
Mahmoud, Osama;Granell, Raquel;Henderson, John
通讯作者：
Henderson, John
影响因子：
3
作者：
Bunn, Andrew G.
通讯作者：
Bunn, Andrew G.