Molecular and cellular mechanisms of the age-dependency of opioid analgesia and tolerance.
Molecular and cellular mechanisms of the age-dependency of opioid analgesia and tolerance.
复制标题
阿片类镇痛和耐受年龄依赖性的分子和细胞机制
DOI：
10.1186/1744-8069-8-38
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发表时间：
2012-05-21
期刊：
影响因子：
3.3
通讯作者：
Huang YG
中科院分区：
文献类型：
--
作者：
Zhao J;Xin X;Xie GX;Palmer PP;Huang YG
The age-dependency of opioid analgesia and tolerance has been noticed in both clinical observation and laboratory studies. Evidence shows that many molecular and cellular events that play essential roles in opioid analgesia and tolerance are actually age-dependent. For example, the expression and functions of endogenous opioid peptides, multiple types of opioid receptors, G protein subunits that couple to opioid receptors, and regulators of G protein signaling (RGS proteins) change with development and age. Other signaling systems that are critical to opioid tolerance development, such as N-methyl-D-aspartic acid (NMDA) receptors, also undergo age-related changes. It is plausible that the age-dependent expression and functions of molecules within and related to the opioid signaling pathways, as well as age-dependent cellular activity such as agonist-induced opioid receptor internalization and desensitization, eventually lead to significant age-dependent changes in opioid analgesia and tolerance development.
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影响因子：
4.7
作者：
Clark, JD
通讯作者：
Clark, JD
DOI：
10.1016/0165-3806(94)90024-8
发表时间：
1994-04-15
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
DEVRIES, TJ;JONKER, AJ;SCHOFFELMEER, ANM
通讯作者：
SCHOFFELMEER, ANM
DOI：
10.1016/j.molbrainres.2003.11.009
发表时间：
2004-02-05
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Ferrer-Alcón, M;La Harpe, R;García-Sevilla, JA
通讯作者：
García-Sevilla, JA
影响因子：
5.3
作者：
HARA, H;TANAKA, T;KISHIMOTO, S
通讯作者：
KISHIMOTO, S
影响因子：
5.3
作者：
Debic, HH;Kim, KA;von Zastrow, M
通讯作者：
von Zastrow, M