No association between body composition and walking outcomes in multiple sclerosis.
No association between body composition and walking outcomes in multiple sclerosis.
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多发性硬化症的身体成分与步行结果之间没有关联。
DOI：
10.1016/j.msard.2022.104242
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发表时间：
2022
影响因子：
4
通讯作者：
Motl,RobertW
中科院分区：
文献类型：
--
作者：
Jeng,Brenda;Motl,RobertW
背景体重超标的一个主要问题是身体机能减退。与肥胖相关的超重会给患有慢性神经系统疾病的人的身体功能带来挑战，特别是步行能力。有证据表明，与对照组相比，多发性硬化症(MS)患者的行走能力显著降低；然而，在MS患者中，身体成分和步行结果之间的关系尚未得到很好的定义。为此，该研究通过广泛分布的体重指数对MS患者的身体组成指标和一系列综合步行结果之间的关系进行了研究。方法动态MS患者(n=)接受了使用扩展残疾状态量表(EDSS)和身体组成指标(即身体脂肪百分比、脂肪质量、瘦质量、骨矿含量和密度)的神经功能障碍评估。参与者随后完成了计时25英尺步行(T25FW)、计时起跑(TUG)、6分钟步行(6 MW)和12项多发性硬化症步行量表(MSWs-12)。我们检验了体脂百分比、脂肪质量、瘦质量、骨矿含量和密度、T25FW、TUG、6 MW、MSWs-12和EDSS之间的等级-顺序相关性。结果身体成分指标与T25FW(rS=-11、.12)、TUG(rS=-0.04、.11)、6 mW(rS=-0.01、0.20)和MSWs-12(rS=-0.16、0.03)无显著相关性。值得注意的是，身体成分指标与基于EDSS的残疾状况没有相关性(rS=-.11，.03)。即使在控制了EDSS之后，身体成分指标与步行结果也没有相关性。结论我们的数据表明，较差的身体成分特征并不一定与MS中更差的步行能力、更多地感受到MS相关的步行障碍或更严重的残疾状况有关，未来的研究可能会考虑在MS中检查其他与健康相关的或超重或肥胖的疾病后果，我们的发现表明，身体成分的优化可能不是改善步行结果的干预措施的目标，未来的研究可能会探索影响MS身体功能降低的其他因素。
BackgroundOne major concern of excess body weight is diminished physical function. The excess body weight associated with obesity can bring about challenges for physical function, particularly walking performance, among persons living with the consequences of a chronic, neurological disease. There is evidence that persons with multiple sclerosis (MS) have significantly reduced walking performance compared with controls; however, the relationship between body composition and walking outcomes has not been well-defined in persons with MS. To that end, the study examined the associations between body composition metrics and a comprehensive battery of walking outcomes in persons with MS recruited across a wide distribution of body mass index.MethodsAmbulatory participants with MS (n=64) underwent an assessment of neurological disability status using the Expanded Disability Status Scale (EDSS) and body composition metrics (i.e., percent body fat, fat mass, lean mass, bone mineral content and density) using dual-energy x-ray absorptiometry. Participants then completed the Timed 25-Foot Walk (T25FW), Timed Up and Go (TUG), 6-Minute Walk (6MW), and 12-Item Multiple Sclerosis Walking Scale (MSWS-12). We examined Spearman rank-order bivariate correlations among percent body fat, fat mass, lean mass, bone mineral content and density, T25FW, TUG, 6MW, MSWS-12, and EDSS.ResultsBody composition metrics were not significantly associated with T25FW (rs=-.11, .12), TUG (rs=-.04, .11), 6MW (rs=-.01, .20), and MSWS-12 (rs=-.16, .03). Of note, body composition metrics were not correlated with disability status based on EDSS (rs=-.11, .03). Body composition metrics were not associated with walking outcomes even after controlling for EDSS.ConclusionOur data indicated that worse body composition profiles are not necessarily associated with worse walking performance, greater perception of MS-related walking impairment, or more severe disability status in MS. Future research may consider examining other health-related or disease outcomes of overweight or obesity in MS. Overall, our findings suggest that optimization of body composition may not be a target of interventions for improving walking outcomes, and future research might explore other factors that influence lower physical function in MS.
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