Glaucoma and biomechanics.
Glaucoma and biomechanics.
复制标题
青光眼和生物力学。
DOI：
10.1097/icu.0000000000000829
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发表时间：
2022-03-01
影响因子：
3.7
通讯作者：
Ethier CR
中科院分区：
文献类型：
--
作者：
Safa BN;Wong CA;Ha J;Ethier CR
生物力学是一个重要方面的复杂家庭的疾病称为脊髓灰质炎。在这里，我们回顾了青光眼生物力学的最新研究。几种组织在各种形式的青光眼中具有直接和/或间接的生物力学作用，包括小梁网、角膜、视乳头周围巩膜、视神经乳头/鞘和虹膜。在小梁网和视神经乳头中继续鉴定多种机械感觉机制和信号通路。此外，最近的文献描述了多种研究组织生物力学作为青光眼危险因素的作用的方法，包括小梁网的病理性硬化、乳头周围巩膜结构变化和视神经乳头的重塑。最后，在青光眼手术中结合生物力学信息方面取得了进展，包括闭角型青光眼的角膜生物力学参数和虹膜机械特性。生物力学仍然是青光眼研究的一个活跃方面，在基础科学和临床翻译方面都很活跃。然而，生物力学在青光眼中的作用仍不完全清楚。因此，进一步的研究表明，以确定新的治疗方法，利用生物力学。重要的是，还需要对青光眼中的组织生物力学特性进行适当的测定的临床翻译。
Biomechanics is an important aspect of the complex family of diseases known as the glaucomas. Here we review recent studies of biomechanics in glaucoma. Several tissues have direct and/or indirect biomechanical roles in various forms of glaucoma, including the trabecular meshwork, cornea, peripapillary sclera, optic nerve head/sheath, and iris. Multiple mechanosensory mechanisms and signaling pathways continue to be identified in both the trabecular meshwork and optic nerve head. Further, the recent literature describes a variety of approaches for investigating the role of tissue biomechanics as a risk factor for glaucoma, including pathological stiffening of the trabecular meshwork, peripapillary scleral structural changes, and remodeling of the optic nerve head. Finally, there have been advances in incorporating biomechanical information in glaucoma prognoses, including corneal biomechanical parameters and iridial mechanical properties in angle-closure glaucoma. Biomechanics remains an active aspect of glaucoma research, with activity in both basic science and clinical translation. However, the role of biomechanics in glaucoma remains incompletely understood. Therefore, further studies are indicated to identify novel therapeutic approaches that leverage biomechanics. Importantly, clinical translation of appropriate assays of tissue biomechanical properties in glaucoma are also needed.
影响因子：
--
作者：
Wan KH;Leung CKS
通讯作者：
Leung CKS
影响因子：
5.7
作者：
Boazak EM;King R;Wang J;Chu CM;Toporek AM;Sherwood JM;Overby DR;Geisert EE;Ethier CR
通讯作者：
Ethier CR