Tissue engineering strategies for the regeneration of orthopedic interfaces.
Tissue engineering strategies for the regeneration of orthopedic interfaces.
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DOI：
10.1007/s10439-010-0046-y
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发表时间：
2010-06
影响因子：
3.8
通讯作者：
Zhang, Xinzhi
中科院分区：
文献类型：
--
作者：
Lu, Helen H.;Subramony, Siddarth D.;Boushell, Margaret K.;Zhang, Xinzhi
关键词：
骨科组织工程领域的一个主要焦点是开发具有仿生功能的组织工程化骨和软组织移植物，以使其转化为临床环境。这一奋进的最重大挑战之一是促进这些移植物彼此以及植入部位的生物固定。这种固定需要将战略仿生学纳入支架设计，以重建天然软组织-骨界面的关键结构-功能关系。不同组织类型（例如，骨和软组织，如软骨、韧带或肌腱）的整合需要具有不同但连续的组织区域的多相或分层支架，伴随着模拟骨和软组织之间的多组织过渡的机械性质梯度。这篇综述讨论了组织工程策略再生常见的组织-组织界面（韧带-骨，肌腱-骨或软骨-骨），和战略仿生实施多层支架设计多组织再生。还将介绍这一新兴领域的潜在挑战和未来方向。可以预见，界面组织工程将使综合性软组织修复，并将有助于开发具有仿生复杂性和功能性的复杂肌肉骨骼组织系统。
A major focus in the field of orthopaedic tissue engineering is the development of tissue engineered bone and soft tissue grafts with biomimetic functionality to allow for their translation to the clinical setting. One of the most significant challenges of this endeavor is promoting the biological fixation of these grafts with each other as well as the implant site. Such fixation requires strategic biomimicry to be incorporated into the scaffold design in order to re-establish the critical structure-function relationship of the native soft tissue-to-bone interface. The integration of distinct tissue types (e.g. bone and soft tissues such as cartilage, ligaments, or tendons), requires a multi-phased or stratified scaffold with distinct yet continuous tissue regions accompanied by a gradient of mechanical properties that mimics that of the multi-tissue transition between bone and soft tissues. This review discusses tissue engineering strategies for regenerating common tissue-to-tissue interfaces (ligament-to-bone, tendon-to-bone or cartilage-to-bone), and the strategic biomimicry implemented in stratified scaffold design for multi-tissue regeneration. Potential challenges and future directions in this emerging field will also be presented. It is anticipated that interface tissue engineering will enable integrative soft tissue repair, and will be instrumental for the development of complex musculoskeletal tissue systems with biomimetic complexity and functionality.
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DOI：
10.1115/1.1318906
发表时间：
2000-12-01
影响因子：
1.7
作者：
Butler, DL;Goldstein, SA;Guilak, F
通讯作者：
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DOI：
10.1002/jbm.820291107
发表时间：
1995-11-01
期刊：
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影响因子：
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影响因子：
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发表时间：
1983-01-01
影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/j.arthro.2006.12.031
发表时间：
2007-05-01
影响因子：
4.7
作者：
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