Residential exposure to 50 Hz magnetic fields and the association with miscarriage risk: a 2-year prospective cohort study.
Residential exposure to 50 Hz magnetic fields and the association with miscarriage risk: a 2-year prospective cohort study.
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DOI：
10.1371/journal.pone.0082113
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Chen L
中科院分区：
文献类型：
--
作者：
Wang Q;Cao Z;Qu Y;Peng X;Guo S;Chen L
关于暴露于极低频磁场(ELF-MF)是否会增加流产风险的假说存在争议。一项为期两年的前瞻性队列研究旨在研究居住在珠江三角洲中国地区的妇女暴露于50赫兹磁场与流产风险之间的关系。选择了两个供电设施密集的乡镇作为研究地点。从2010年到2012年，该地区552名怀孕约8周或计划在1年内生育的妇女被选为候选对象。通过在受试者的前门和受试者房屋前的巷子里进行测量来估计暴露在MF中的量。平均暴露水平被用作界定暴露组的分界点。临床流产由当地产科医生诊断。当地人口和计划生育服务站的工作人员负责每2个月进行一次跟踪访谈。413名孕妇被选为队列研究对象。居民平均暴露于MF为0.099微米。未发现流产风险显著增加与平均前门暴露有关(p>；0.05)。然而，流产风险被发现与最大巷子暴露显著相关(p=0.001)。最大巷道暴露导致流产的相对危险度(RR)为2.35(95%可信区间：1.18-4.71)。COX回归分析显示，调整后的最大巷道暴露流产危险比为1.72(95%可信区间：1.10~2.69)。尽管流产发生率与巷子中最大的MF暴露呈正相关，但流产风险与暴露于MF之间的关系在研究中并未得到证实。这项研究的结果与MF暴露评估和妊娠结局有关。
The hypothesis of whether exposure to extremely low-frequency magnetic fields (ELF-MF) may increase miscarriage risk is controversial. A 2-year prospective cohort study was designed to study the association between exposure to 50 Hz magnetic fields (MF) and the miscarriage risk for women residing in the area of the Pearl-River Delta of China. Two towns with densely distributed power supply constructions were selected as the study sites. From 2010 to 2012, 552 women in the region who were at approximately 8 weeks of gestation or who planned to have a baby within 1 year were selected as candidate subjects. Exposure to MF was estimated by measurements at their front doors and in the alley in front of the subjects’ houses. The average exposure level was used as a cutoff point to define the exposed group. Clinical miscarriage was diagnosed by local obstetricians. Staffs from the local population and family planning service stations were responsible for the follow-up interviews every 2 months. Four hundred and thirteen pregnant women were selected for the cohort study. The average residential exposure to MF was 0.099 µT. No significantly increased risk of miscarriage was found to be associated with the average front-door exposure (p>0.05). However, miscarriage risk was found to be significantly associated with maximum alley exposure (p=0.001). The relative risk (RR) of miscarriage from maximum alley exposure was 2.35 (95% C.I.: 1.18-4.71). In addition, Cox regression analysis showed that the adjusted hazard ratio of maximum alley exposure for miscarriage was 1.72 (95% C.I.:1.10-2.69). Although the miscarriage incidence was shown to be positively associated with the maximum alley MF exposure, the association between miscarriage risk and the exposure to MF was not confirmed in the study. The results of this study are of interest concerning MF exposure assessment and pregnancy outcomes.
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