Non-Motor Symptoms of Parkinson's Disease: The Neurobiology of Early Psychiatric and Cognitive Dysfunction.
Non-Motor Symptoms of Parkinson's Disease: The Neurobiology of Early Psychiatric and Cognitive Dysfunction.
复制标题
帕金森病的非运动症状：早期精神和认知功能障碍的神经生物学。
DOI：
10.1177/10738584211011979
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发表时间：
2023-03
期刊：
影响因子：
5.6
通讯作者：
Huntley, George W.
中科院分区：
文献类型：
--
作者：
Hussein, Ayan;Guevara, Christopher A.;Del Valle, Pamela;Gupta, Swati;Benson, Deanna L.;Huntley, George W.
关键词：
帕金森病（PD）是一种进行性神经退行性疾病，200多年来一直被认为是其临床上占主导地位的运动系统损害。也有突出的非运动症状，其中，抑郁和焦虑以及认知障碍的精神症状很常见，并且可能比运动症状更早出现。虽然这些特定PD相关非运动症状的神经生物学基础尚未完全理解，但对导致遗传性和散发性PD的PARK基因的鉴定已经使动物中的遗传模型成为可能，这反过来又促进了对与人类PD的非运动精神和认知症状相关的细胞，突触，电路和行为的不断深入的分析。此外，虽然人们早就认识到炎症是PD的重要组成部分，但最近的研究表明，脑免疫信号串扰在精神症状的背景下对脑细胞和突触功能具有显著的调节作用。这篇综述提供了一个重点更新的进展，了解PD相关的非运动精神和认知症状的神经生物学。
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that has been recognized for over 200 years by its clinically dominant motor system impairment. There are prominent non-motor symptoms as well, and among these, psychiatric symptoms of depression and anxiety and cognitive impairment are common and can appear earlier than motor symptoms. Although the neurobiology underlying these particular PD-associated non-motor symptoms is not completely understood, the identification of PARK genes that contribute to hereditary and sporadic PD has enabled genetic models in animals that, in turn, have fostered ever deepening analyses of cells, synapses, circuits, and behaviors relevant to non-motor psychiatric and cognitive symptoms of human PD. Moreover, while it has long been recognized that inflammation is a prominent component of PD, recent studies demonstrate that brain-immune signaling crosstalk has significant modulatory effects on brain cell and synaptic function in the context of psychiatric symptoms. This review provides a focused update on such progress in understanding the neurobiology of PD-related non-motor psychiatric and cognitive symptoms.
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