Profound context-dependent plasticity of mitral cell responses in olfactory bulb.
Profound context-dependent plasticity of mitral cell responses in olfactory bulb.
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DOI：
10.1371/journal.pbio.0060258
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发表时间：
2008-10-28
期刊：
影响因子：
9.8
通讯作者：
Restrepo D
中科院分区：
文献类型：
--
作者：
Doucette W;Restrepo D
根据嗅球的初级回路，有人认为嗅球类似于哺乳动物的视网膜。在视网膜中，重复暴露于相同的视觉刺激导致神经表征随着时间的推移保持相对稳定，即使刺激对动物的意义发生变化。稳定的刺激表示在早期阶段的处理允许无偏的解释传入的刺激高阶皮层中心。另一种选择是，早期刺激表征是由先前导出的意义塑造的，这可以允许对气味空间进行更有效的采样，从而提供对传入刺激的简化但有偏见的解释。这项研究有助于将嗅觉系统置于主观与客观早期感觉表征的连续统一体上。在这里，我们表明，气味的输出细胞的OB，二尖瓣细胞的反应，改变瞬态在一个去不去气味辨别任务。响应变化以增加电路传递区分密切相关的气味所需的信息的能力的方式发生。值得注意的是，在两种气味中哪一种得到奖励之间的转换会导致二尖瓣细胞改变其不同反应的极性。总之，这些结果重新定义的功能的OB作为一个短暂的可修改的（主动）过滤器，塑造早期的气味表征在行为上有意义的方式。大脑代表和处理感官信息的方式仍然是一个基本问题。一种模型假定，在刺激处理的早期阶段，刺激的稳定神经表征允许高阶皮层中心对传入刺激进行无偏解释。或者，早期刺激表征可以由先前的经验塑造，从而提供对传入刺激的有偏见但相关的解释。本研究探讨了在气味辨别任务中，嗅球中气味信息处理的第一阶段的输出细胞，僧帽细胞的活动。我们发现，气味反应在任务过程中改变的方式，增加了电路的能力，以传达必要的信息，以区分密切相关的气味。两种气味之间的转换会导致二尖瓣细胞以与行为相关的方式转换其不同反应的极性。这些结果表明，早期的气味神经表征可以通过先前推导的意义来塑造，为更高的皮层结构提供了一个简化但有偏见的气味环境解释。气味的早期神经表征可以通过先前推导的意义来塑造，为高级皮层结构提供了对气味环境的简化但有偏见的解释。
On the basis of its primary circuit it has been postulated that the olfactory bulb (OB) is analogous to the retina in mammals. In retina, repeated exposure to the same visual stimulus results in a neural representation that remains relatively stable over time, even as the meaning of that stimulus to the animal changes. Stability of stimulus representation at early stages of processing allows for unbiased interpretation of incoming stimuli by higher order cortical centers. The alternative is that early stimulus representation is shaped by previously derived meaning, which could allow more efficient sampling of odor space providing a simplified yet biased interpretation of incoming stimuli. This study helps place the olfactory system on this continuum of subjective versus objective early sensory representation. Here we show that odor responses of the output cells of the OB, mitral cells, change transiently during a go–no-go odor discrimination task. The response changes occur in a manner that increases the ability of the circuit to convey information necessary to discriminate among closely related odors. Remarkably, a switch between which of the two odors is rewarded causes mitral cells to switch the polarity of their divergent responses. Taken together these results redefine the function of the OB as a transiently modifiable (active) filter, shaping early odor representations in behaviorally meaningful ways. The way in which the brain represents and processes sensory information remains a fundamental question. One model posits that stable neural representation of a stimulus during early stages of stimulus processing allows for unbiased interpretation of incoming stimuli by higher order cortical centers. Alternately, early stimulus representation could be shaped by previous experience, thus providing a biased yet relevant interpretation of incoming stimuli. This study examines the activity of output cells, mitral cells, from the first stage of odor information processing in the olfactory bulb during an odor discrimination task. We found that odor responses changed during the task in a manner that increased the ability of the circuit to convey information necessary to discriminate among closely related odors. A switch between which of the two odors were rewarded caused mitral cells to switch the polarity of their divergent responses in behaviorally relevant ways. These results show that early neural representations of odor can be shaped by previously derived meaning, providing a simplified yet biased interpretation of the odor environment to higher cortical structures. Early neural representation of odor can be shaped by previously derived meaning, providing a simplified yet biased interpretation of the odor environment to higher cortical structures.
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影响因子：
5.3
作者：
Cohen, Yaniv;Reuveni, Iris;Maroun, Mouna
通讯作者：
Maroun, Mouna
影响因子：
16.2
作者：
Abraham, NM;Spors, H;Schaefer, AT
通讯作者：
Schaefer, AT
DOI：
10.1073/pnas.0401902101
发表时间：
2004-07-13
影响因子：
11.1
作者：
Daly, KC;Christensen, TA;Hildebrand, JG
通讯作者：
Hildebrand, JG
影响因子：
2.5
作者：
Illig, KR
通讯作者：
Illig, KR
DOI：
10.1073/pnas.0608564104
发表时间：
2007-02-06
影响因子：
11.1
作者：
Cleland, Thomas A.;Johnson, Brett A.;Linster, Christiane
通讯作者：
Linster, Christiane