Flumazenil prevents the development of chlordiazepoxide withdrawal in rats tested in the social interaction test of anxiety
Flumazenil prevents the development of chlordiazepoxide withdrawal in rats tested in the social interaction test of anxiety
复制标题
氟马西尼可预防焦虑社交互动测试中大鼠利眠宁戒断的发生
DOI：
10.1007/bf00439464
复制
发表时间：
2004
影响因子：
3.4
通讯作者：
S. File
中科院分区：
文献类型：
--
作者：
H. Baldwin;S. File
Rats were chronically treated with chlordiazepoxide (CDP 10 mg/kg/day) or vehicle for 27 days. Twenty-four hours after their last dose, they received flumazenil (4 mg/kg) or vehicle and were tested in the social interaction test, in a low-light, familiar arena. CDP withdrawal significantly reduced the time spent in social interaction compared with controls, indicating an anxiogenic withdrawal response. This was completely reversed by flumazenil. A second group received CDP for 27 days and, in addition, received a single dose of flumazenil (4 mg/kg) 6 days before testing. Flumazenil prevented the development of the anxiogenic withdrawal response in these rats.
定期给予苯二氮卓类拮抗剂可预防灵长类动物的苯二氮卓类戒断症状。
影响因子：
5
作者：
Gallager,DW;Heninger,K;Heninger,G
通讯作者：
Heninger,G
重复施用 RO 15-1788 对苯二氮卓依赖狒狒的影响。
影响因子：
5
作者：
Lamb,RJ;Griffiths,RR
通讯作者：
Griffiths,RR