Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration.
Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration.
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DOI：
10.1002/ana.24052
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发表时间：
2014-01
影响因子：
11.2
通讯作者：
Boxer, Adam L.
中科院分区：
文献类型：
--
作者：
Scherling, Carole S.;Hall, Tracey;Berisha, Flora;Klepac, Kristen;Karydas, Anna;Coppola, Giovanni;Kramer, Joel H.;Rabinovici, Gil;Ahlijanian, Michael;Miller, Bruce L.;Seeley, William;Grinberg, Lea T.;Rosen, Howard;Meredith, Jere, Jr.;Boxer, Adam L.
脑脊液（CSF）神经丝轻链（NfL）浓度在包括额颞叶变性（FTD）在内的神经疾病中升高。我们研究了FTD患者脑脊液NfL水平升高的临床相关性。比较47例正常人（NC）、8例FTD致突变无症状基因携带者（NC2）、79例FTD（45例行为变异性额颞叶痴呆[bvFTD]、18例进行性非流畅性失语症[PNFA]、16例语意性痴呆[SD]）、22例进行性核上性麻痹、50例阿尔茨海默病、6例帕金森病和17例皮质基底综合征患者脑脊液NfL、淀粉样蛋白-β42 （Aβ42）、tau和磷酸化tau （ptau）浓度。脑脊液分析物水平之间的相关性采用神经心理学测量和临床痴呆评定量表（CDRsb）。基于体素的结构MR图像形态测定确定了脑容量与脑脊液NfL之间的关系。bvFTD、SD和PNFA组脑脊液NfL平均浓度高于其他组。NC2的NfL与NC相似。脑脊液NfL与FTD患者的CDRsb和神经心理学测量相关，而与其他脑脊液测量无关，而与其他诊断组无关。对两个独立的FTD队列和一组尸检证实或生物标志物丰富的病例的分析证实了更大的组分析。在FTD中，灰质和白质体积与CSF NfL浓度呈负相关，因此NfL水平最高的个体萎缩最严重。脑脊液NfL在有症状的FTD中升高，并与疾病严重程度相关。在FTD临床试验中，这一测量可能是一个有用的疾病严重程度的替代终点。FTD患者脑脊液NfL的纵向研究是有必要的。
Cerebrospinal fluid (CSF) neurofilament light chain (NfL) concentration is elevated in neurological disorders including frontotemporal degeneration (FTD). We investigated the clinical correlates of elevated CSF NfL levels in FTD. CSF NfL, amyloid-β42 (Aβ42), tau and phosphorylated tau (ptau) concentrations were compared in 47 normal controls (NC), 8 asymptomatic gene carriers (NC2) of FTD-causing mutations, 79 FTD (45 behavioral variant frontotemporal dementia [bvFTD], 18 progressive nonfluent aphasia [PNFA], 16 semantic dementia [SD]), 22 progressive supranuclear palsy, 50 Alzheimer’s disease, 6 Parkinson’s disease and 17 corticobasal syndrome patients. Correlations between CSF analyte levels were performed with neuropsychological measures and the Clinical Dementia Rating scale sum of boxes (CDRsb). Voxel-based morphometry of structural MR images determined the relationship between brain volume and CSF NfL. Mean CSF NfL concentrations were higher in bvFTD, SD and PNFA than other groups. NfL in NC2 was similar to NC. CSF NfL, but not other CSF measures, correlated with CDRsb and neuropsychological measures in FTD, and not in other diagnostic groups. Analyses in two independent FTD cohorts and a group of autopsy verified or biomarker enriched cases confirmed the larger group analysis. In FTD, gray and white matter volume negatively correlated with CSF NfL concentration, such that individuals with highest NfL levels exhibited the most atrophy. CSF NfL is elevated in symptomatic FTD and correlates with disease severity. This measurement may be a useful surrogate endpoint of disease severity in FTD clinical trials. Longitudinal studies of CSF NfL in FTD are warranted.
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影响因子：
11
作者：
Lycke, JN;Karlsson, JE;Rosengren, LE
通讯作者：
Rosengren, LE
影响因子：
48
作者：
Petersen, Ronald C.
通讯作者：
Petersen, Ronald C.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
64.8
作者：
Baker, Matt;Mackenzie, Ian R.;Hutton, Mike
通讯作者：
Hutton, Mike
影响因子：
2.7
作者：
Kramer, JH;Miller, BL
通讯作者：
Miller, BL