Experimental Modeling of Host-Bacterial Interactions in Head and Neck Squamous Cell Carcinoma.
Experimental Modeling of Host-Bacterial Interactions in Head and Neck Squamous Cell Carcinoma.
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DOI：
10.3390/cancers15245810
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发表时间：
2023-12-12
期刊：
影响因子：
5.2
通讯作者：
Parikh, Anuraag S.
中科院分区：
文献类型：
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作者：
Okolo, Ogoegbunam;Honzel, Emily;Britton, William R.;Yu, Victoria X.;Flashner, Samuel;Martin, Cecilia;Nakagawa, Hiroshi;Parikh, Anuraag S.
关键词：
微生物组已经在体内稳态和疾病状态下实施，包括癌症的机理研究，迄今为止，微生物组在头颈部鳞状细胞癌中的作用（HNSCC）是迄今为止的相对婴儿，文献表明，在HNSCC中，Microbiome在HNSCC中的造成了验证。传统的单层培养物，3D器官培养物和3D器官可能有助于表征微生物组和HNSCC之间复杂关系的基础，目的是改善风险分层并最终指导治疗。
统称人体的微观物种在维持组织稳态，免疫学和疾病的发展中起着至关重要的作用。但是，在癌中；与2D模型相比研究微生物组在HNSCC中的作用的领域；
The microbiome has been implicated in both homeostasis and disease states, including cancer. Mechanistic investigations into the role of the microbiome in head and neck squamous cell carcinoma (HNSCC) are in their relative infancy. To date, the literature suggests an altered microbiome in subjects with HNSCC, but the mechanisms behind these changes remain to be elucidated. The use of in vitro models utilizing co-culture of cancer cells with microbes, including traditional monolayer culture, 3D organotypic culture, and 3D organoids, may help characterize the underpinnings of the complex relationship between the microbiome and HNSCC, with the goal of improving risk stratification and ultimately guiding treatment. The microscopic species colonizing the human body, collectively referred to as the microbiome, play a crucial role in the maintenance of tissue homeostasis, immunity, and the development of disease. There is evidence to suggest associations between alterations in the microbiome and the development of head and neck squamous cell carcinomas (HNSCC). The use of two-dimensional (2D) modeling systems has made significant strides in uncovering the role of microbes in carcinogenesis; however, direct mechanistic links remain in their infancy. Patient-derived three-dimensional (3D) HNSCC organoid and organotypic models have recently been described. Compared to 2D models, 3D organoid culture systems effectively capture the genetic and epigenetic features of parent tissue in a patient-specific manner and may offer a more nuanced understanding of the role of host–microbe responses in carcinogenesis. This review provides a topical literature review assessing the current state of the field investigating the role of the microbiome in HNSCC; including in vivo and in vitro modeling methods that may be used to characterize microbiome–epithelial interactions.
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影响因子：
3.7
作者：
Dickinson BC;Moffatt CE;Hagerty D;Whitmore SE;Brown TA;Graves DT;Lamont RJ
通讯作者：
Lamont RJ
影响因子：
4.6
作者：
Bugueno, Isaac Maximiliano;Batool, Fareeha;Huck, Olivier
通讯作者：
Huck, Olivier
影响因子：
5.6
作者：
Andrian, Elisoa;Mostefaoui, Yakout;Grenier, Daniel
通讯作者：
Grenier, Daniel
影响因子：
3.6
作者：
Annavajhala MK;May M;Compres G;Freedberg DE;Graham R;Stump S;Que J;Korem T;Uhlemann AC;Abrams JA
通讯作者：
Abrams JA
DOI：
10.3390/medsci11020042
发表时间：
2023-06-13
期刊：
Medical sciences (Basel, Switzerland)
影响因子：
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作者：
通讯作者：
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