Negative expression of N-acetylglucosaminyltransferase V in oral squamous cell carcinoma correlates with poor prognosis.
Negative expression of N-acetylglucosaminyltransferase V in oral squamous cell carcinoma correlates with poor prognosis.
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DOI：
10.1186/2193-1801-2-657
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Bukawa H
中科院分区：
文献类型：
--
作者：
Seto K;Uchida F;Baba O;Yamatoji M;Karube R;Warabi E;Sakai S;Hasegawa S;Yamagata K;Yanagawa T;Onizawa K;Miyoshi E;Shoda J;Bukawa H
N-乙酰葡糖胺转移酶V（GnT-V）是一种在天冬酰胺连接寡糖分支中起关键作用的酶，与许多实体瘤的肿瘤侵袭和转移密切相关。在这里，我们寻找口腔鳞状细胞癌（OSCC）患者的临床特征和肿瘤中GnT-V表达之间的相关性，我们研究了使用GnT-V作为口腔癌预后标志物的可行性。采用免疫组化方法检测68例口腔鳞癌组织中GnT-V的表达，并分析GnT-V在口腔鳞癌组织中的表达水平与患者临床特征的关系。GnT-V阳性表达48例（70.6%），阴性表达20例（29.4%）。多因素Logistic回归分析显示GnT-V阴性表达与肿瘤的浸润方式有关（OR：3.605; P = 0.048）。GnT-V阴性表达的肿瘤生物学特性和Ki-67标记指数高于GnT-V阳性表达的肿瘤，但差异无统计学意义（P = 0.176）。GnT-V表达阴性的患者生存期明显短于GnT-V表达阳性的患者（5年生存率分别为58.2%和86.5%; P = 0.025）。GnT-V阴性表达是OSCC预后不良的重要因素（危险比4.246; P = 0.045）。GnT-V表达的缺失可能是OSCC患者中肿瘤侵袭潜力高和预后差的一个指标。
N-acetylglucosaminyltransferase V (GnT-V), an enzyme with a key role in the branching of asparagine-linked oligosaccharides, is strongly linked to tumor invasion and metastasis of many solid tumors. Here we searched for correlations between the clinical features of patients with oral squamous cell carcinoma (OSCC) and GnT-V expression in the tumor, and we studied the feasibility of using GnT-V as a marker for oral cancer prognosis. Samples from 68 patients with OSCC were examined by immunohistochemistry using antibodies against GnT-V. Correlations between the expression level of GnT-V in the tumor and patient clinical features were statistically analyzed. Positive GnT-V expression was found in 48 cases (70.6%), and negative GnT-V expression was found in 20 cases (29.4%). Negative GnT-V expression was associated with mode of invasion by multiple logistic regression analysis (OR: 3.605; P = 0.048). Biological characteristics of tumors and the Ki-67 labeling index were higher in tumors with negative GnT-V expression than in those with positive GnT-V expression, although the difference was not significant (P = 0.176). Patients with negative GnT-V expression had significantly shorter survival than those with tumors having positive GnT-V expression (5-year survival rate, 58.2% and 86.5%, respectively; P = 0.025). Negative GnT-V expression was a significant unfavorable prognostic factor for OSCC (hazard ratio, 4.246; P = 0.045). The loss of GnT-V expression is a likely indicator of tumors with high potential of tumor invasion and poor prognosis in OSCC patients.
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影响因子：
8.8
作者：
通讯作者：
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影响因子：
5
作者：
Chen, Yi-Ting;Chong, Yi-Min;Chang, Chuan-Fa
通讯作者：
Chang, Chuan-Fa
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254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P
影响因子：
158.5
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Forastiere, AA;Goepfert, H;Cooper, J
通讯作者：
Cooper, J
影响因子：
4.8
作者：
Saito, T;Miyoshi, E;Taniguchi, N
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Taniguchi, N