Mammary gland adipocytes in lactation cycle, obesity and breast cancer.
Mammary gland adipocytes in lactation cycle, obesity and breast cancer.
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哺乳周期中的乳腺脂肪细胞、肥胖与乳腺癌。
DOI：
10.1007/s11154-021-09633-5
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发表时间：
2021-06
影响因子：
8.2
通讯作者：
Cinti S
中科院分区：
文献类型：
--
作者：
Colleluori G;Perugini J;Barbatelli G;Cinti S
乳腺(MG)是雌性哺乳动物体内的一个外分泌腺，负责哺乳过程中乳汁的产生和分泌。它主要由上皮细胞和脂肪细胞组成。MG的独特之处在于：1)它在怀孕、哺乳和退化过程中表现出高度的可塑性(所有阶段都属于哺乳周期)；2)它要求与脂肪细胞紧密结合生长，这对于确保MG在青春期的正常发育和哺乳周期中的重塑是绝对必要的。虽然MG脂肪细胞在腺体发育中起着至关重要的作用，但大多数研究仅集中在其上皮成分上，而对邻近脂肪细胞的作用还没有很大程度的探讨。在这篇综述中，我们旨在描述有关MG脂肪细胞在生理条件(腺体发育和哺乳期)、肥胖和乳腺癌中的作用和特性的证据，强调现有文献中存在的空白，值得进一步研究。
The mammary gland (MG) is an exocrine gland present in female mammals responsible for the production and secretion of milk during the process of lactation. It is mainly composed by epithelial cells and adipocytes. Among the features that make the MG unique there are 1) its highly plastic properties displayed during pregnancy, lactation and involution (all steps belonging to the lactation cycle) and 2) its requirement to grow in close association with adipocytes which are absolutely necessary to ensure MG’s proper development at puberty and remodeling during the lactation cycle. Although MG adipocytes play such a critical role for the gland development, most of the studies have focused on its epithelial component only, leaving the role of the neighboring adipocytes largely unexplored. In this review we aim to describe evidences regarding MG’s adipocytes role and properties in physiologic conditions (gland development and lactation cycle), obesity and breast cancer, emphasizing the existing gaps in the literature which deserve further investigation.
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影响因子：
5.9
作者：
Balaban S;Shearer RF;Lee LS;van Geldermalsen M;Schreuder M;Shtein HC;Cairns R;Thomas KC;Fazakerley DJ;Grewal T;Holst J;Saunders DN;Hoy AJ
通讯作者：
Hoy AJ
影响因子：
4.3
作者：
Cinti S
通讯作者：
Cinti S
糖尿病和非糖尿病肥胖患者的肌肉和脂肪组织形态，胰岛素敏感性和β细胞功能：减肥手术的影响。
影响因子：
4.6
作者：
Camastra S;Vitali A;Anselmino M;Gastaldelli A;Bellini R;Berta R;Severi I;Baldi S;Astiarraga B;Barbatelli G;Cinti S;Ferrannini E
通讯作者：
Ferrannini E
影响因子：
5.6
作者：
Giordano A;Perugini J;Kristensen DM;Sartini L;Frontini A;Kajimura S;Kristiansen K;Cinti S
通讯作者：
Cinti S
影响因子：
5.8
作者：
Cozzo AJ;Fuller AM;Makowski L
通讯作者：
Makowski L