From genotype to functional phenotype: unraveling the metabolomic features of colorectal cancer.
From genotype to functional phenotype: unraveling the metabolomic features of colorectal cancer.
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DOI：
10.3390/genes5030536
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发表时间：
2014-07-22
期刊：
影响因子：
3.5
通讯作者：
Farshidfar F
中科院分区：
文献类型：
--
作者：
Bathe OF;Farshidfar F
近年来，人们在确定结直肠癌及其亚型的基因组和表观遗传学改变方面付出了很多努力。然而，对与各种亚型相关的功能分支知之甚少。代谢组学研究疾病中的小分子中间体，为结直肠癌的功能表型提供了一个快照。到目前为止，数据已经描述了伴随结直肠癌的一些代谢紊乱。然而，需要进一步的研究来确定生物学上有意义的代谢亚群，包括那些与特定遗传畸变相对应的亚群。此外，还需要进一步的研究来区分肿瘤引起的变化和宿主对肿瘤的反应。
Much effort in recent years has been expended in defining the genomic and epigenetic alterations that characterize colorectal adenocarcinoma and its subtypes. However, little is known about the functional ramifications related to various subtypes. Metabolomics, the study of small molecule intermediates in disease, provides a snapshot of the functional phenotype of colorectal cancer. Data, thus far, have characterized some of the metabolic perturbations that accompany colorectal cancer. However, further studies will be required to identify biologically meaningful metabolic subsets, including those corresponding to specific genetic aberrations. Moreover, further studies are necessary to distinguish changes due to tumor and the host response to tumor.
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影响因子：
14.9
作者：
Chatr-Aryamontri A;Breitkreutz BJ;Heinicke S;Boucher L;Winter A;Stark C;Nixon J;Ramage L;Kolas N;O'Donnell L;Reguly T;Breitkreutz A;Sellam A;Chen D;Chang C;Rust J;Livstone M;Oughtred R;Dolinski K;Tyers M
通讯作者：
Tyers M
影响因子：
37.3
作者：
Denkert C;Budczies J;Weichert W;Wohlgemuth G;Scholz M;Kind T;Niesporek S;Noske A;Buckendahl A;Dietel M;Fiehn O
通讯作者：
Fiehn O
影响因子：
8
作者：
Buzzai, M;Bauer, DE;Thompson, CB
通讯作者：
Thompson, CB
影响因子：
9.6
作者：
Crozier, J. E. M.;Mckee, R. F.;McMillan, D. C.
通讯作者：
McMillan, D. C.
影响因子：
--
作者：
Francipane MG;Lagasse E
通讯作者：
Lagasse E