Comparison of 24 different adjuvants for inactivated HIV-2 split whole virus as antigen in mice. Induction of titres of binding antibodies and toxicity of the formulations.
Comparison of 24 different adjuvants for inactivated HIV-2 split whole virus as antigen in mice. Induction of titres of binding antibodies and toxicity of the formulations.
复制标题
24种不同佐剂对灭活的HIV-2裂解全病毒作为小鼠抗原的比较。
DOI：
10.1016/0264-410x(95)80010-b
复制
发表时间：
1995
期刊：
影响因子：
5.5
通讯作者：
J. Kreuter
中科院分区：
文献类型：
--
作者：
F. Stieneker;G. Kersten;L. van Bloois;D. Crommelin;S. Hem;J. Löwer;J. Kreuter
The objective of this study was the comparison of the quantity and quality of the humoral immune response against inactivated whole human immunodeficiency virus type 2. Twenty-four different adjuvants were tested. The toxicity of these preparations was determined. Due to the large number of experiments, the animal model used was the NMRI mouse. Sera were assayed for the presence of antibodies by ELISA and Western blot. The toxicity of the adjuvants was determined by observing lethal side-effects occurring within two days after injection of the immunogenic preparations. The results show that polymethylmethacrylate nanoparticles were the best overall adjuvant, inducing the highest titres of antibodies compared with other adjuvants as well as producing a significantly better immune response against a number of individual HIV-2 antigens without any observable toxic side-effects. However, this adjuvant did not induce antibodies against the outer envelope protein gp120, whereas such antibodies were induced by aluminium compounds, Freund's complete and incomplete adjuvants, and fumed silica (Aerosil). This result suggests the necessity of using vaccines with two or more different adjuvants in order to induce the required immune response against physically different antigens.
DOI：
10.1073/pnas.85.9.3198
发表时间：
1988-05
影响因子：
11.1
作者：
James R. Rusche;K. Javaherian;Charlene MCDANALt;J. Petro;Debra L. Lynn;R. Grimaila;Alphonse J. LANGLOISt;Robert C. Gallo;P. Fischinger;Dani P. BOLOGNESIt;SCOTr D. Putney;Thomas J. MATTHEWSt
通讯作者：
James R. Rusche;K. Javaherian;Charlene MCDANALt;J. Petro;Debra L. Lynn;R. Grimaila;Alphonse J. LANGLOISt;Robert C. Gallo;P. Fischinger;Dani P. BOLOGNESIt;SCOTr D. Putney;Thomas J. MATTHEWSt
由脂质体相关蛋白抗原介导的免疫反应。
影响因子：
6.4
作者：
Shek,PN;Lopez,NG;Heath,TD
通讯作者：
Heath,TD
对由人类免疫缺陷病毒 1 型 (HIV-1) 或 HIV-1 外膜糖蛋白 (gp120) 制备的免疫刺激复合物 (ISCOM) 的免疫反应。
影响因子：
5.5
作者：
Pyle,SW;Morein,B;BessJr,JW;Akerblom,L;Nara,PL;NigidaJr,SM;Lerche,NW;Robey,WG;Fischinger,PJ;Arthur,LO
通讯作者：
Arthur,LO