Parthenogenesis doubles the rate of amino acid substitution in whiptail mitochondria
Parthenogenesis doubles the rate of amino acid substitution in whiptail mitochondria
复制标题
孤雌生殖使鞭尾线粒体中氨基酸取代率加倍
DOI：
10.1111/evo.14509
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发表时间：
2022
期刊：
影响因子：
3.3
通讯作者：
Fujita, Matthew K.
中科院分区：
文献类型：
--
作者：
Maldonado, Jose A.;Firneno, Thomas J.;Hall, Alexander S.;Fujita, Matthew K.
有性生殖在自然界中无处不在，这表明与无性生殖相比，性必须有广泛的好处来克服雄性的成本。有一个假设性的优势有强有力的理论支持，即性在从基因组中去除有害突变方面发挥作用。理论预测，向无性生殖的转变应该会导致重组和分离的抑制，反过来，削弱自然选择，允许轻微有害突变的积累。我们测试了这一预测，估计dN/dSratios在无性脊椎动物谱系的属Aspidoscelisususing整个线粒体基因组从7个无性和5个有性物种。我们发现在asexualAspidoscelisspecies较高的dN/dS比，表明无性鞭尾积累非同义替换由于较弱的纯化选择。此外，我们估计了核苷酸多样性，发现无性繁殖者的多样性明显较少。因此，尽管它们的起源较近，但轻微有害的突变在无性系中积累得足够快，足以被检测到。我们提供了经验证据来证实无性生殖和无性生殖脊椎动物谱系中氨基酸取代增加之间的联系。
Sexual reproduction is ubiquitous in the natural world, suggesting that sex must have extensive benefits to overcome the cost of males compared to asexual reproduction. One hypothesized advantage of sex with strong theoretical support is that sex plays a role in removing deleterious mutations from the genome. Theory predicts that transitions to asexuality should lead to the suppression of recombination and segregation and, in turn, weakened natural selection, allowing for the accumulation of slightly deleterious mutations. We tested this prediction by estimating the dN/dSratios in asexual vertebrate lineages in the genusAspidoscelisusing whole mitochondrial genomes from seven asexual and five sexual species. We found higher dN/dSratios in asexualAspidoscelisspecies, indicating that asexual whiptails accumulate nonsynonymous substitutions due to weaker purifying selection. Additionally, we estimated nucleotide diversity and found that asexuals harbor significantly less diversity. Thus, despite their recent origins, slightly deleterious mutations accumulated rapidly enough in asexual lineages to be detected. We provide empirical evidence to corroborate the connection between asexuality and increased amino acid substitutions in asexual vertebrate lineages.
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