Breathing-driven prefrontal oscillations regulate maintenance of conditioned-fear evoked freezing independently of initiation.
Breathing-driven prefrontal oscillations regulate maintenance of conditioned-fear evoked freezing independently of initiation.
复制标题
呼吸驱动的前额叶振荡调节条件性恐惧诱发的冻结独立启动的维护。
DOI：
10.1038/s41467-021-22798-6
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发表时间：
2021-05-10
影响因子：
16.6
通讯作者：
Benchenane K
中科院分区：
文献类型：
--
作者：
Bagur S;Lefort JM;Lacroix MM;de Lavilléon G;Herry C;Chouvaeff M;Billand C;Geoffroy H;Benchenane K
大脑与身体的相互作用被认为是情绪中必不可少的，但其生理基础仍然知之甚少。在小鼠中，在线索恐惧条件反射后的冻结期间出现规则的4 Hz呼吸。在这里，我们表明，嗅球（OB）将这种节奏传递到背内侧前额叶皮层（dmPFC），在那里它组织神经活动。通过球切除术或OB的光遗传学扰动减少与勃起相关的4 Hz振荡，减少冻结。行为建模表明，这是由于冻结维护的具体减少，而不影响其启动，从而分离这两种现象。dmPFC LFP和发射模式支持该区域在冻结维护中的特定功能。特别是，人口分析表明，网络活动跟踪4 Hz的功率动态冻结期间，并达到一个稳定的状态在4 Hz的峰值，持续到冻结终止。这些结果提供了一个潜在的机制和功能作用的身体反馈的情绪，因此阐明了历史上的詹姆斯-坎农的辩论。结合光遗传学，行为建模和神经群体分析，作者在小鼠中表明，在与恐惧相关的冻结期间，嗅球将4 Hz的呼吸节奏传输到前额叶皮层，这种振荡组织局部活动并调节冻结事件持续时间。
Brain–body interactions are thought to be essential in emotions but their physiological basis remains poorly understood. In mice, regular 4 Hz breathing appears during freezing after cue-fear conditioning. Here we show that the olfactory bulb (OB) transmits this rhythm to the dorsomedial prefrontal cortex (dmPFC) where it organizes neural activity. Reduction of the respiratory-related 4 Hz oscillation, via bulbectomy or optogenetic perturbation of the OB, reduces freezing. Behavioural modelling shows that this is due to a specific reduction in freezing maintenance without impacting its initiation, thus dissociating these two phenomena. dmPFC LFP and firing patterns support the region’s specific function in freezing maintenance. In particular, population analysis reveals that network activity tracks 4 Hz power dynamics during freezing and reaches a stable state at 4 Hz peak that lasts until freezing termination. These results provide a potential mechanism and a functional role for bodily feedback in emotions and therefore shed light on the historical James–Cannon debate. Combining optogenetics, behavioral modelling and neural population analysis, the authors show in mice that during fear-related freezing the olfactory bulb transmits 4 Hz breathing rhythm to the prefrontal cortex where this oscillation organizes local activity and regulates freezing episode duration.
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影响因子：
1.1
作者：
Bechara, A;Damasio, AR
通讯作者：
Damasio, AR
影响因子：
5.8
作者：
Dutschmann，Mathias;Dick，Thomas E.
通讯作者：
Dick，Thomas E.
DOI：
10.1523/jneurosci.4122-11.2012
发表时间：
2012-01-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Belluscio MA;Mizuseki K;Schmidt R;Kempter R;Buzsáki G
通讯作者：
Buzsáki G
影响因子：
3
作者：
DAVEY, NJ;ELLAWAY, PH;STEIN, RB
通讯作者：
STEIN, RB
影响因子：
25
作者：
Fukunaga, Izumi;Herb, Jan T.;Kollo, Mihaly;Boyden, Edward S.;Schaefer, Andreas T.
通讯作者：
Schaefer, Andreas T.