The relationship between muscle sympathetic nerve activity and systemic hemodynamics is altered in women with uterine fibroids.
The relationship between muscle sympathetic nerve activity and systemic hemodynamics is altered in women with uterine fibroids.
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DOI：
10.14814/phy2.15445
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发表时间：
2022-09
影响因子：
2.5
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中科院分区：
文献类型：
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患有子宫肌瘤（UF）（子宫肌层良性肿瘤）的女性比没有子宫肌瘤的女性患高血压的患病率更高。这种关系的原因尚不清楚。肌肉交感神经活动 (MSNA) 是动脉血压的调节因子，MSNA 的变化可能会使患有 UF 的女性容易患上高血压。本研究的目的是评估患有或不患有 UF 的女性的基线血压和 MSNA 以及 MSNA 与全身血流动力学之间的关系。我们测量了 14 名健康、血压正常、患有 UF 的绝经前女性（42±2岁）和 9 名健康、血压正常、未患有 UF 的绝经前女性（41±2岁）静息时的血压（肱动脉内线）、MSNA（显微神经造影）和全身血流动力学（总外周阻力和心输出量）。各组之间的基线血压和 MSNA 没有差异（两者均 p > 0.05）。在患有UF的女性中，MSNA与总外周阻力呈正相关（r= 0.75，p= 0.02），MSNA与心输出量呈负相关（r= −0.73，p= 0.03）。相比之下，在没有 UF 的女性中没有发现这些关系（两种关系的 p > 0.05）。这些数据表明，患有UF的健康女性与未患UF的健康女性相比，自主神经与全身血流动力学的相互作用以及血压调节是不同的。在患有子宫肌瘤的女性中，肌肉交感神经活动与总外周阻力呈正相关，但在没有子宫肌瘤的女性中则不然。与没有子宫肌瘤的健康女性相比，患有子宫肌瘤的女性（原本健康）的自主神经与全身血流动力学的相互作用以及血压调节是不同的。
Women with uterine fibroids (UF), benign tumors of the myometrium, have a higher prevalence of hypertension than women without UF. The cause for this relationship is unclear. Muscle sympathetic nerve activity (MSNA) is a regulator of arterial blood pressure, and it is possible that variations in MSNA predispose women with UF to develop hypertension. The purpose of this study was to assess baseline blood pressure and MSNA and the relationships between MSNA and systemic hemodynamics in women with and without UF. We measured blood pressure (brachial intra‐arterial line), MSNA (microneurography), and systemic hemodynamics (total peripheral resistance and cardiac output) at rest in 14 healthy, normotensive, premenopausal women with UF (42 ± 2 years old) and 9 healthy, normotensive, premenopausal women without UF (41 ± 2 years old). Baseline blood pressure and MSNA did not differ between groups (p > 0.05 for both). In women with UF, there was a positive correlation between MSNA and total peripheral resistance (r = 0.75, p = 0.02), as well as a negative correlation between MSNA and cardiac output (r = −0.73, p = 0.03). In contrast, these relationships were not seen in women without UF (p > 0.05 for both relationships). These data suggest that autonomic interactions with systemic hemodynamics, and thus blood pressure regulation, are different in healthy women with UF compared to healthy women without UF. Muscle sympathetic nerve activity is positively correlated with total peripheral resistance in women with uterine fibroids but not in women without uterine fibroids. Autonomic interactions with systemic hemodynamics, and thus blood pressure regulation, are different in women with uterine fibroids (who are otherwise healthy) compared to healthy women without uterine fibroids.
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影响因子：
--
作者：
Cretoiu, Sanda M;Popescu, Laurentiu M
通讯作者：
Popescu, Laurentiu M
影响因子：
3.3
作者：
Aleksandrovych, Veronika;Kurnik-Lucka, Magdalena;Gil, Krzysztof
通讯作者：
Gil, Krzysztof
影响因子：
0.9
作者：
Ascensao, Tania;Leite, Helena Barros;Aguas, Fernanda
通讯作者：
Aguas, Fernanda
影响因子：
6.1
作者：
Radin, R. G.;Rosenberg, L.;Wise, L. A.
通讯作者：
Wise, L. A.
影响因子：
5.5
作者：
Hart, Emma C.;Charkoudian, Nisha;Joyner, Michael J.
通讯作者：
Joyner, Michael J.