Genomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018.
Genomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018.
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DOI：
10.1038/s41598-021-89070-1
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发表时间：
2021-05-14
影响因子：
4.6
通讯作者：
Ndiaye D
中科院分区：
文献类型：
--
作者：
Gaye A;Ndiaye T;Sy M;Deme AB;Thiaw AB;Sene A;Ndiaye C;Diedhiou Y;Mbaye AM;Ndiaye I;Tomkins-Tinch C;Gomis JF;Badiane AS;MacInnis B;Park DJ;Ndiaye M;Sy N;Sabeti PC;Siddle KJ;Ndiaye D
登革热病毒是全球热带和亚热带地区一个主要且迅速增长的公共卫生问题。 2018年底，塞内加尔经历了迄今为止最大规模的登革热病毒疫情，覆盖多个地区。然而，人们对塞内加尔登革热病毒（DENV）的遗传多样性知之甚少。在此，我们报告了蒂耶市 17 例之前未发现的 DENV 病例的完整病毒基因组。我们在 2018 年 10 月和 11 月收集的 198 名发热个体中总共发现了 19 例 DENV 病例。我们检测到了 3 种共同循环的血清型； DENV 3 是最常见的序列，占 11/17 序列 (65%)，DENV2 占 4 个序列 (23%)，DENV1 占 2 个序列 (12%)。序列与西非最近的序列最相似，表明病毒种群正在局部循环；然而，详细的推断受到可用基因组数据稀缺的限制。我们没有发现与报告的临床体征或症状之间存在明确的关联，这凸显了检测诊断发热性疾病的重要性。总体而言，这些发现扩大了塞内加尔 DENV 的已知范围，并强调需要更好地研究西非 DENV 的基因组特征。
Dengue virus is a major and rapidly growing public health concern in tropic and subtropic regions across the globe. In late 2018, Senegal experienced its largest dengue virus outbreak to date, covering several regions. However, little is known about the genetic diversity of dengue virus (DENV) in Senegal. Here we report complete viral genomes from 17 previously undetected DENV cases from the city of Thiès. In total we identified 19 cases of DENV in a cohort of 198 individuals with fever collected in October and November 2018. We detected 3 co-circulating serotypes; DENV 3 was the most frequent accounting for 11/17 sequences (65%), 4 (23%) were DENV2 and 2 (12%) were DENV1. Sequences were most similar to recent sequences from West Africa, suggesting ongoing local circulation of viral populations; however, detailed inference is limited by the scarcity of available genomic data. We did not find clear associations with reported clinical signs or symptoms, highlighting the importance of testing for diagnosing febrile diseases. Overall, these findings expand the known range of DENV in Senegal, and underscore the need for better genomic characterization of DENV in West Africa.
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影响因子：
11.8
作者：
Shihada S;Emmerich P;Thomé-Bolduan C;Jansen S;Günther S;Frank C;Schmidt-Chanasit J;Cadar D
通讯作者：
Cadar D
空间和时间尺度之间的登革率多样性：局部结构以及宿主种群规模的影响。
DOI：
10.1126/science.aaj9384
发表时间：
2017-03-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Salje H;Lessler J;Maljkovic Berry I;Melendrez MC;Endy T;Kalayanarooj S;A-Nuegoonpipat A;Chanama S;Sangkijporn S;Klungthong C;Thaisomboonsuk B;Nisalak A;Gibbons RV;Iamsirithaworn S;Macareo LR;Yoon IK;Sangarsang A;Jarman RG;Cummings DA
通讯作者：
Cummings DA
DOI：
10.4269/ajtmh.2008.79.218
发表时间：
2008-08-01
影响因子：
3.3
作者：
Huber, Karine;Ba, Yamar;Diallo, Mawlouth
通讯作者：
Diallo, Mawlouth
影响因子：
10.7
作者：
Hoang DT;Chernomor O;von Haeseler A;Minh BQ;Vinh LS
通讯作者：
Vinh LS
影响因子：
12.3
作者：
Breitwieser FP;Baker DN;Salzberg SL
通讯作者：
Salzberg SL