Anomalous diffusion in supported lipid bilayers induced by oxide surface nanostructures.

Anomalous diffusion in supported lipid bilayers induced by oxide surface nanostructures.
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由氧化物表面纳米结构诱导的支持的脂质双层中的异常扩散。

DOI:
10.1021/la201474h
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发表时间:
2011
期刊:
Langmuir : the ACS journal of surfaces and colloids
影响因子:
--
通讯作者:
T. Urisu
T. Urisu
中科院分区:
--
文献类型:
--
作者:
R. Tero;G. Sazaki;T. Ujihara;T. Urisu

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将分层结构和亚微米尺度上的异常扩散引入人工细胞膜,并在纳米结构的氧化物表面上可视化脂质扩散的时空依赖性。采用单分子跟踪(SMT)方法,观察了阶梯状TiO(2)(100)和非晶态SiO(2)/Si表面支撑脂质双分子层(slb)中的脂质扩散。在500 μs ~ 30 ms的时间分辨率下,SMT可以在100 nm/ ms ~ 1 μm/s的时间和空间范围内观察到脂质扩散。SLB中扩散系数随TiO(2)(100)的时间依赖性表明,从异常扩散到随机扩散的交叉发生在10 ms左右。衬底上的表面精细结构将适用于诱导100 nm或更小的层次结构,这与体内的微室尺寸相对应。
Hierarchic structure and anomalous diffusion on submicrometer scale were introduced into an artificial cell membrane, and the spatiotemporal dependence of lipid diffusion was visualized on nanostructured oxide surfaces. We observed the lipid diffusion in supported lipid bilayers (SLBs) on step-and-terrace TiO(2)(100) and amorphous SiO(2)/Si surfaces by single molecule tracking (SMT) method. The SMT at the time resolution of 500 μs to 30 ms achieved observation of the lipid diffusion over the spatial and temporal ranges of 100 nm/millisecond to 1 μm/second. The temporal dependence of the diffusion coefficient in the SLB on TiO(2)(100) showed that the crossover from anomalous diffusion to random diffusion occurred around 10 ms. The surface fine architecture on substrates will be applicable to induce hierarchic structures on the order of 100 nm or less, which correspond to the microcompartment size in vivo.
DOI: 10.1016/s0006-3495(94)80789-1
发表时间: 1994-02-01
影响因子: 3.4
作者:
SAXTON, MJ
通讯作者: SAXTON, MJ
DOI: 10.1016/s0006-3495(95)79911-8
发表时间: 1995-08-01
影响因子: 3.4
作者:
SAXTON, MJ
通讯作者: SAXTON, MJ
DOI: 10.1016/s0006-3495(96)79682-0
发表时间: 1996-03-01
影响因子: 3.4
作者:
Saxton, MJ
通讯作者: Saxton, MJ