Association of serum osteoprotegerin with left ventricular mass in African American adults with hypertension.
Association of serum osteoprotegerin with left ventricular mass in African American adults with hypertension.
复制标题
非洲裔美国成人高血压患者血清骨保护素与左心室质量的关系。
DOI：
10.1038/ajh.2010.59
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发表时间：
2010
影响因子：
3.2
通讯作者：
Kullo,IftikharJ
中科院分区：
文献类型：
--
作者：
Noheria,Amit;MosleyJr,ThomasH;Kullo,IftikharJ
背景患有高血压的非裔美国人易患左心室肥厚(LVH)。血清护骨素水平与左心室肥厚有关。我们调查了898名患有高血压的非裔美国人(平均年龄65岁，71%的女性)骨保护素水平与左心室重量(LVM)的关系。应用M型超声心动图测定LVM指数(LVMi；LVm/Height2.7)。结果血清护骨素与LVMI呈正相关(r=0.0001.2 1；P<0.0 1)，LVMI最高组较最低组增加5.0 5(95%可信区间2.93，7.17)g/m2.7。在调整了常规心血管危险因素(年龄、性别、体重指数(BMI)、吸烟史、糖尿病、收缩压(BP)、总和高密度脂蛋白胆固醇)、估计的肾功能、心肌梗塞和中风史、生活方式因素(体力活动评分、教育年限、饮酒量)、药物(阿司匹林、抗高血压药、他汀类药物、雌激素)和C反应蛋白(CRP)后，这种相关性在统计学上仍然显著(P=0.02)。此外，护骨素水平与E/A比值(r=−0.16；P<；0.0001)、左心室平均室壁厚度(r=0.17；P<；0.0001)和相对室壁厚度(r=0.14；P<；0.0001)相关，但与射血分数(r=0.04；P=0.24)或舒张末内径(r=0.02；P=0.6)无关。
BackgroundAfrican-Americans with hypertension are susceptible to left ventricular hypertrophy (LVH). Serum osteoprotegerin level has been reported to be associated with LVH. We investigated the association of osteoprotegerin with LV mass (LVM) in 898 African-Americans with hypertension (mean age 65 years, 71% women).MethodsOsteoprotegerin levels were measured in serum by an immunoassay and log-transformed for analyses. LVM index (LVMi; LVM/height2.7) was estimated using M-mode echocardiography. Linear regression analyses using generalized estimating equations were used to assess the association of osteoprotegerin with LVMi.ResultsSerum osteoprotegerin was correlated with LVMi (r= 0.21;P< 0.0001), an estimated increase in LVMi of 5.05 (95% confidence interval 2.93, 7.17) g/m2.7in the highest compared to the lowest osteoprotegerin quartile. This association remained statistically significant after adjustment for conventional cardiovascular risk factors (age, sex, body mass index (BMI), history of smoking, diabetes, systolic blood pressure (BP), total and high-density lipoprotein cholesterol), estimated renal function, history of myocardial infarction and stroke, lifestyle factors (physical activity score, years of education, amount of alcohol consumption), medications (aspirin, antihypertensives, statins, estrogens), and C-reactive protein (CRP) (P= 0.02). Additionally, osteoprotegerin was correlated with early/atrial (E/A) ratio (r= −0.16;P< 0.0001), LV mean wall thickness (r= 0.17;P< 0.0001) and relative wall thickness (r= 0.14;P< 0.0001) but not ejection fraction (r= 0.04;P= 0.24) or internal end-diastolic dimension (r= 0.02;P= 0.60).ConclusionIn African-Americans with hypertension, a higher serum osteoprotegerin level is weakly but independently associated with a higher LVM.
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影响因子：
37.8
作者：
Jono, S;Ikari, Y;Nishizawa, Y
通讯作者：
Nishizawa, Y
DOI：
10.1016/0735-1097(92)90385-z
发表时间：
1992-11-01
影响因子：
24
作者：
DESIMONE, G;DANIELS, SR;ALDERMAN, MH
通讯作者：
ALDERMAN, MH
透皮 17β-雌二醇对高血压女性左心室解剖和性能的影响。
影响因子：
8.3
作者：
M. G. Modena;N. Muià;P. Aveta;R. Molinari;R. Rossi
通讯作者：
R. Rossi
DOI：
--
发表时间：
2000
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
U. Malyankar;M. Scatena;K. Suchland;T. Yun;E. Clark;C. Giachelli
通讯作者：
U. Malyankar;M. Scatena;K. Suchland;T. Yun;E. Clark;C. Giachelli
影响因子：
8.3
作者：
Omland, Torbjorn;Drazner, Mark H.;de Lemos, James A.
通讯作者：
de Lemos, James A.