One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial.
One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial.
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DOI：
10.1093/ajcn/nqac255
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发表时间：
2022-12-19
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影响因子：
--
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胆碱和甜菜碱的摄入量与心血管健康有关。我们的目的是在PREDIMED(Prevención con Dieta地中海)Plus试验的框架内，探讨饮食中胆碱或甜菜碱摄入量的1年变化与心代谢和肾功能指标1年变化的关系。我们使用西班牙PREDIMED-Plus试验中5613名参与者(48.2%女性和51.8%男性；平均年龄：65.01岁±44.91岁)的基线和1年随访数据来评估心脏代谢特征，并使用3367名参与者来评估肾功能。参与者符合≥3代谢综合征标准，并有超重或肥胖[体重指数(以公斤/平方米为单位)≥27和≤40]。这些标准与PREDIMED父母研究的标准相似。膳食中胆碱和甜菜碱的摄入量由FFQ估算。膳食中胆碱或甜菜碱摄入量(第四分位)的最大1年增幅与血糖浓度(胆碱和甜菜碱的−分别为3.39和−2.72 mg/dL)和糖化血红蛋白水平(胆碱或甜菜碱摄入量增加的第四分位的−为0.10%)有关。与胆碱或甜菜碱摄入量增加最大相关的其他显著变化是体重下降(分别为−2.93和−2.78)、体重指数(分别为−1.05和−0.99)、腰围(分别为−3.37和−3.26 cm)、总胆固醇(分别为4.74和−4.52 mg/dL)以及低密度脂蛋白(分别为−4.30和−4.16 mg/dL)。胆碱或甜菜碱摄入量增加一年，尿肌酐降低四分位数(分别为−5.42和−5.74 mg/dL)。膳食胆碱或甜菜碱摄入量的增加纵向上与心脏代谢参数的改善有关。肾功能指标也略有改善，需要进一步研究。这项试验在https://www.isrctn.com/注册为ISRCTN89898870。
Choline and betaine intakes have been related to cardiovascular health. We aimed to explore the relation between 1-y changes in dietary intake of choline or betaine and 1-y changes in cardiometabolic and renal function traits within the frame of the PREDIMED (PREvención con DIeta MEDiterránea)-Plus trial. We used baseline and 1-y follow-up data from 5613 participants (48.2% female and 51.8% male; mean ± SD age: 65.01 ± 4.91 y) to assess cardiometabolic traits, and 3367 participants to assess renal function, of the Spanish PREDIMED-Plus trial. Participants met ≥3 criteria of metabolic syndrome and had overweight or obesity [BMI (in kg/m2) ≥27 and ≤40]. These criteria were similar to those of the PREDIMED parent study. Dietary intakes of choline and betaine were estimated from the FFQ. The greatest 1-y increase in dietary choline or betaine intake (quartile 4) was associated with improved serum glucose concentrations (−3.39 and −2.72 mg/dL for choline and betaine, respectively) and HbA1c levels (−0.10% for quartile 4 of either choline or betaine intake increase). Other significant changes associated with the greatest increase in choline or betaine intake were reduced body weight (−2.93 and −2.78 kg, respectively), BMI (−1.05 and −0.99, respectively), waist circumference (−3.37 and −3.26 cm, respectively), total cholesterol (−4.74 and −4.52 mg/dL, respectively), and LDL cholesterol (−4.30 and −4.16 mg/dL, respectively). Urine creatinine was reduced in quartile 4 of 1-y increase in choline or betaine intake (−5.42 and −5.74 mg/dL, respectively). Increases in dietary choline or betaine intakes were longitudinally related to improvements in cardiometabolic parameters. Markers of renal function were also slightly improved, and they require further investigation. This trial was registered at https://www.isrctn.com/ as ISRCTN89898870.
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