High calorie intake is associated with worsening insulin resistance and β-cell function in Hispanic women after gestational diabetes mellitus.
High calorie intake is associated with worsening insulin resistance and β-cell function in Hispanic women after gestational diabetes mellitus.
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DOI：
10.2337/dc14-1433
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发表时间：
2014-12
期刊：
影响因子：
16.2
通讯作者：
Xiang AH
中科院分区：
文献类型：
--
作者：
Chen Z;Watanabe RM;Stram DO;Buchanan TA;Xiang AH
评估既往患有妊娠糖尿病（GDM）的西班牙裔女性的饮食摄入与胰岛素抵抗和β细胞功能变化率之间的关系。62例妊娠合并GDM的非糖尿病西班牙裔女性在产后每12-15个月完成口服和静脉葡萄糖耐量试验和体脂生物电阻抗测量，持续长达12年。通过为西班牙裔开发的结构化食物频率问卷，在所有访视时收集自我报告的饮食摄入量。采用混合效应模型评估随访期间饮食摄入量与代谢结果变化率之间的关系。从第一次产后评估开始的中位随访时间为8.0年（四分位距4.5-10.8年）。基线时，女性年龄为32 ± 5.7岁，平均卡路里摄入量为2，091千卡/天。在随访过程中，饮食摄入量没有显著变化。随着时间的推移，较高的基线卡路里摄入量与胰岛素敏感性（通过胰岛素敏感性指数（SI）测量）（P = 0.029）和β细胞代偿（通过处置指数（DI）测量）（P = 0.027）的快速下降相关。在调整了基线特征、BMI、卡路里摄入量、体力活动水平的变化以及随访期间的额外怀孕后，这些相关性仍然存在。对于基线卡路里摄入量高于或低于队列中位数的女性，SI的中位数为-0.06 vs.-0.02单位/年，DI的中位数为-810 vs.-692单位/年。高热量摄入与2型糖尿病高危西班牙裔女性胰岛素敏感性和β细胞代偿的快速下降相关，与肥胖无关。
To assess associations between dietary intake and rates of change in insulin resistance and β-cell function in Hispanic women with prior gestational diabetes mellitus (GDM). Sixty-two nondiabetic Hispanic women with pregnancies complicated by GDM completed oral and intravenous glucose tolerance tests and bioelectrical impedance measurements of body fat every 12–15 months postpartum for up to 12 years. Self-reported dietary intake was collected at all visits by structured food frequency questionnaires developed for Hispanics. Mixed-effects models were used to assess the relationship between dietary intake and rates of change in metabolic outcomes during follow-up. The median length of follow-up from the first postpartum evaluation was 8.0 years (interquartile range 4.5–10.8 years). At baseline, women were 32 ± 5.7 years old and had a median calorie intake of 2,091 kcal/day. Over the course of follow-up, dietary intake did not change significantly. Higher baseline calorie intake was associated with a faster decline in insulin sensitivity, measured by the insulin sensitivity index (SI) (P = 0.029), and β-cell compensation, measured by the disposition index (DI) (P = 0.027), over time. These associations remained after adjustment for baseline characteristics; changes in BMI, calorie intake, levels of physical activity; and additional pregnancies during the follow-up period. The median rates were −0.06 vs. −0.02 units/year for SI and −810 vs. −692 units/year for DI for women with baseline calorie intake above versus below the cohort median. High calorie intake is associated with a faster decline in insulin sensitivity and β-cell compensation in Hispanic women who are at high risk for type 2 diabetes, independent of adiposity.
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影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
影响因子：
4.5
作者：
van den Berg SA;Guigas B;Bijland S;Ouwens M;Voshol PJ;Frants RR;Havekes LM;Romijn JA;van Dijk KW
通讯作者：
van Dijk KW
影响因子：
--
作者：
DESPRES, JP;POULIOT, MC;BOUCHARD, C
通讯作者：
BOUCHARD, C
影响因子：
5.8
作者：
Utzschneider, KM;Carr, DB;Schwartz, RS
通讯作者：
Schwartz, RS
影响因子：
16.2
作者：
Larson-Meyer, D. Enette;Heilbronn, Leonie K.;Ravussin, Eric
通讯作者：
Ravussin, Eric