Gut microbiota variations in patients diagnosed with major depressive disorder-A systematic review.
Gut microbiota variations in patients diagnosed with major depressive disorder-A systematic review.
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DOI：
10.1002/brb3.2177
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发表时间：
2021-07
影响因子：
3.1
通讯作者：
Sørensen S
中科院分区：
文献类型：
--
作者：
Knudsen JK;Bundgaard-Nielsen C;Hjerrild S;Nielsen RE;Leutscher P;Sørensen S
重度抑郁症（MDD）的病因是多因素的，并且与肠道微生物群的扰动有关。因此，确定MDD患者肠道微生物群的任何变化非常重要。进行了系统性文献检索，包括基于在MDD患者中进行的肠道微生物群研究的原始研究文章。在纳入的研究之间比较了人口统计学和临床特征、应用的方法学和观察到的肠道微生物群组成。共纳入了17项研究，共738例MDD患者和782例健康对照，使用不同的DNA纯化方法，测序平台和数据分析模型。4项研究发现MDD患者的α多样性降低，而12项研究中的肠道微生物群组成根据患者和对照之间的β多样性分别聚类。此外，与健康对照组相比，MDD患者中Eggerthella，Atopobium和Bifidobacterium的相对丰度增加，而Faecalibacterium的相对丰度降低。当比较MDD患者和健康对照时，肠道微生物群显着不同，尽管在研究中不一致。研究之间肠道微生物群组成的异质性可以通过研究设计的变化来解释。与健康对照组相比，诊断为抑郁症的患者的肠道微生物群显着不同。
The etiology of major depressive disorder (MDD) is multi‐factorial and has been associated with a perturbed gut microbiota. Thus, it is therefore of great importance to determine any variations in gut microbiota in patients with MDD. A systematic literature search was conducted including original research articles based on gut microbiota studies performed in patients with MDD. Demographic and clinical characteristics, applied methodology and observed gut microbiota composition were compared between included studies. Seventeen studies were included with a total of 738 patients with MDD and 782 healthy controls using different DNA purification methods, sequencing platforms and data analysis models. Four studies found a reduced α‐diversity in patients with MDD, while gut microbiota compositions clustered separately according to β‐diversity between patients and controls in twelve studies. Additionally, there was an increase in relative abundance of Eggerthella, Atopobium, and Bifidobacterium and a decreased relative abundance of Faecalibacterium in patients with MDD compared with healthy controls. Gut microbiota differs significantly when comparing patients with MDD and healthy controls, though inconsistently across studies. The heterogeneity in gut microbiota compositions between the studies may be explained by variations in study design. The gut microbiota is significantly different in patients diagnosed with depression compared to healthy controls.
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