Structural mass spectrometry of proteins using hydroxyl radical based protein footprinting.

Structural mass spectrometry of proteins using hydroxyl radical based protein footprinting.
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DOI:
10.1021/ac200567u
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发表时间:
2011-10-01
影响因子:
7.4
通讯作者:
Chance, Mark R.
Chance, Mark R.
中科院分区:
化学1区
文献类型:
--
作者:
Wang, Liwen;Chance, Mark R.

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Structural MS is a rapidly growing field with many applications in basic research and pharmaceutical drug development. In this feature article the overall technology is described and several examples of how hydroxyl radical based footprinting MS can be used to map interfaces, evaluate protein structure, and identify ligand dependent conformational changes in proteins are described.
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