Are anticapsular antibodies the primary mechanism of protection against invasive pneumococcal disease?
Are anticapsular antibodies the primary mechanism of protection against invasive pneumococcal disease?
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DOI：
10.1371/journal.pmed.0020015
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发表时间：
2005-01
期刊：
影响因子：
15.8
通讯作者：
Malley R
中科院分区：
文献类型：
--
作者：
Lipsitch M;Whitney CG;Zell E;Kaijalainen T;Dagan R;Malley R
抗荚膜多糖抗体已成为几种疫苗的基础，这些疫苗提供对来自肺炎链球菌的侵袭性疾病的保护。这种疫苗的成功导致了这样的推论，即对侵袭性肺炎球菌疾病的自然保护主要是由抗荚膜抗体赋予的。如果是这样的话，人们可以预期不同血清型的疾病下降会有显著差异，并且抗囊抗体的大量浓度的出现会与年龄特异性发病率的下降在时间上一致。使用来自美国的发病率数据，我们发现，相反，发病率随年龄的下降是非常相似的7个最重要的血清群，尽管在人群中的暴露有很大的差异。此外，在生命的第二年和第三年，抗体浓度仅适度增加，在此期间，特定类型的发病率下降到低于其峰值的25%。我们还提供了以色列幼儿抗体浓度分布的详细数据，这些数据与美国的研究结果一致。同样的结论也得到了芬兰年龄特异性发病率的新数据的支持，并与芬兰幼儿抗体获得的已发表数据进行了比较。我们建议对保护机制进行一些额外的研究，以区分潜在的替代机制，包括对非荚膜抗原的获得性免疫，非特异性免疫反应的成熟，或解剖结构或暴露的变化。疫苗接种诱导的抗荚膜抗体可以预防侵袭性链球菌病，但天然免疫似乎还涉及其他机制
Antibody to capsular polysaccharide has been the basis of several vaccines that offer protection against invasive disease from Streptococcus pneumoniae. The success of such vaccines has led to the inference that natural protection against invasive pneumococcal disease is largely conferred by anticapsular antibody. If this is so, one would expect that the decline in disease from different serotypes would vary significantly, and that the appearance of substantial concentrations of anticapsular antibodies would coincide temporally with the decline in age-specific incidence. Using incidence data from the United States, we show that, on the contrary, the decline in incidence with age is quite similar for the seven most important serogroups, despite large differences in exposure in the population. Moreover, only modest increases in antibody concentration occur over the second and third years of life, a period in which serotype-specific incidence declines to less than 25% of its peak. We also present detailed data on the distribution of antibody concentrations in Israeli toddlers, which are consistent with the United States findings. The same conclusion is supported by new data on age-specific incidence in Finland, which is compared with published data on antibody acquisition in Finnish toddlers. We suggest some additional studies of the mechanisms of protection that could distinguish among potential alternative mechanisms, including acquired immunity to noncapsular antigens, maturation of nonspecific immune responses, or changes in anatomy or exposure. Anticapsular antibodies induced by vaccination can protect against invasive streptococcal disease, but natural immunity seems to involve other mechanism as well
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影响因子：
3.6
作者：
Black, S;Shinefield, H;Edwards, K
通讯作者：
Edwards, K
影响因子：
3.1
作者：
KELLY, T;DILLARD, JP;YOTHER, J
通讯作者：
YOTHER, J
影响因子：
6.4
作者：
Goldenberg, HB;McCool, TL;Weiser, JN
通讯作者：
Weiser, JN
影响因子：
3.1
作者：
TSUI, FP;EGAN, W;ROBBINS, JB
通讯作者：
ROBBINS, JB
DOI：
10.1128/cdli.9.5.1032-1038.2002
发表时间：
2002-09-01
期刊：
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
影响因子：
--
作者：
Soininen, A;Karpala, M;Käyhty, H
通讯作者：
Käyhty, H