A steroid hormone agonist reduces female fitness in insecticide-resistant Anopheles populations.
A steroid hormone agonist reduces female fitness in insecticide-resistant Anopheles populations.
复制标题
DOI：
10.1016/j.ibmb.2020.103372
复制
发表时间：
2020-06
影响因子：
3.8
通讯作者：
Ingham, Victoria A.
中科院分区：
文献类型：
--
作者：
Brown, Faye;Paton, Douglas G.;Catteruccia, Flaminia;Ranson, Hilary;Ingham, Victoria A.
以杀虫剂为基础的媒介控制工具，如经杀虫剂处理的蚊帐和室内滞留喷洒，是疟疾控制方案的基石。对这些方案中使用的化学药物的抗药性现在很普遍，对减少疟疾相关发病率和死亡率方面取得的成果构成了重大威胁。最近，在实验室敏感的冈比亚按蚊种群中，20-羟基蜕皮激素类固醇激素途径的中断被证明减少了疟原虫的发育，并显著降低了寿命和产卵量。在这里，我们证明了应用二苯甲酰肼，甲氧基苯肼(DBH-M)，对抗药性蚊虫的这一途径的破坏。Coluzzii、An.冈比亚亚种Sl和An.无论是局部应用还是鞑靼应用，真菌种群都能显著降低产卵量。此外，DBH-M在局部使用时会减少成虫的寿命，在喂血后会延长寿命。由于在拟除虫菊酯抗性按蚊体内升高的细胞色素P450只与DBH-M结合非常弱，这种化合物在野外环境中不太可能受到交叉抗性的影响。因此，操纵这一荷尔蒙信号通路是当前疟疾控制战略的一种潜在补充方法，特别是在杀虫剂抗药性水平高的地区正在损害现有工具的地区。
Insecticide based vector control tools such as insecticide treated bednets and indoor residual spraying represent the cornerstones of malaria control programs. Resistance to chemistries used in these programs is now widespread and represents a significant threat to the gains seen in reducing malaria-related morbidity and mortality. Recently, disruption of the 20-hydroxyecdysone steroid hormone pathway was shown to reduce Plasmodium development and significantly reduce both longevity and egg production in a laboratory susceptible Anopheles gambiae population. Here, we demonstrate that disruption of this pathway by application of the dibenzoylhydrazine, methoxyfenozide (DBH-M), to insecticide resistant An. coluzzii, An. gambiae sl and An. funestus populations significantly reduces egg production in both topical and tarsal application. Moreover, DBH-M reduces adult longevity when applied topically, and tarsally after blood feeding. As the cytochrome p450s elevated in pyrethroid resistant Anopheles only bind DBH-M very weakly, this compound is unlikely to be subject to cross-resistance in a field-based setting. Manipulation of this hormonal signalling pathway therefore represents a potential complementary approach to current malaria control strategies, particularly in areas where high levels of insecticide resistance are compromising existing tools.
登录
查看更多内容
影响因子：
2.8
作者：
Ishtiaq, M.;Salem, Mushtaq A.;Razaq, M.
通讯作者：
Razaq, M.
影响因子：
1.9
作者：
Hunt, RH;Brooke, BD;Coetzee, M
通讯作者：
Coetzee, M
影响因子：
3
作者：
Bayili, Koama;N'do, Severin;Diabate, Abdoulaye
通讯作者：
Diabate, Abdoulaye
DOI：
10.4269/ajtmh.2003.68.121
发表时间：
2003-04-01
影响因子：
3.3
作者：
Hawley, WA;Phillips-Howard, PA;Hightower, AW
通讯作者：
Hightower, AW
影响因子：
9.8
作者：
Baldini F;Gabrieli P;South A;Valim C;Mancini F;Catteruccia F
通讯作者：
Catteruccia F