In Vivo Confocal Microscopic Observations of Vortex Keratopathy in Patients with Amiodarone-Induced Keratopathy and Fabry Disease.
In Vivo Confocal Microscopic Observations of Vortex Keratopathy in Patients with Amiodarone-Induced Keratopathy and Fabry Disease.
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DOI：
10.1155/2018/5315137
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发表时间：
2018
影响因子：
1.9
通讯作者：
Ohashi Y
中科院分区：
文献类型：
--
作者：
Ikegawa Y;Shiraishi A;Hayashi Y;Ogimoto A;Ohashi Y
比较胺碘酮诱导的角膜病变和法布里病相关角膜病变两种类型的旋涡性角膜病变的形态学。 8例接受口服胺碘酮治疗的患者和3例Fabry病患者，一位母亲和她的2个女儿，定期接受裂隙灯生物显微镜和体内共聚焦显微镜（IVCM）检查。 8例患者中有7例发生胺碘酮诱导的角膜病变，IVCM和裂隙灯生物显微镜分别在第7天和第14天检测到。活体共聚焦显微镜图像显示两种类型角膜病变的角膜上皮细胞聚集，细胞质高度反光。在胺碘酮诱导的角膜病变中，高度反光的上皮细胞首先出现在角膜中心，然后随着胺碘酮给药时间的增加扩散到周边。在法布里病中，一致地观察到从利姆布斯延伸到中央角膜的高反射上皮细胞。 这些结果表明，在胺碘酮诱导的角膜病变中，角膜上皮细胞最可能从泪膜中内吞胺碘酮。在法布里病中，globotriaosylceramide沉积物被角膜缘上皮干细胞的溶酶体吸收，并且它们分化并迁移到角膜中心以形成螺旋图案。
To compare the morphology of two types of vortex keratopathy: amiodarone-induced keratopathy and the Fabry disease-associated keratopathy. Eight patients who were receiving oral amiodarone therapy and 3 patients with Fabry disease, a mother and her 2 daughters, were examined by slit-lamp biomicroscopy and in vivo confocal microscopy (IVCM) regularly. Amiodarone-induced keratopathy developed in 7 of the 8 patients, and it was detected as early as 7 days by IVCM and 14 days by slit-lamp biomicroscopy. The in vivo confocal microscopic images showed a clustering of corneal epithelial cells with a highly reflective cytoplasm in both types of keratopathy. In the amiodarone-induced keratopathy, the highly reflective epithelial cells were first found at the center of the cornea and then spread to the periphery with increasing time on amiodarone. In Fabry disease, the highly reflective epithelial cells were consistently observed extending from the limbus to the central cornea. These findings suggest that the corneal epithelial cells most likely endocytose amiodarone from the tear film in the amiodarone-induced keratopathy. In Fabry disease, globotriaosylceramide deposits are taken up by the lysosomes of the limbal epithelial stem cells, and they differentiate and migrate to the center of the cornea to form the whorl pattern.
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影响因子：
1.2
作者：
Dorà NJ;Hill RE;Collinson JM;West JD
通讯作者：
West JD
影响因子：
--
作者：
KAPLAN, LJ;CAPPAERT, WE
通讯作者：
CAPPAERT, WE
影响因子：
4.4
作者：
Nagasaki, T;Zhao, J
通讯作者：
Zhao, J
DOI：
10.1007/s00417-011-1726-5
发表时间：
2011-11-01
影响因子：
2.7
作者：
Wasielica-Poslednik, Joanna;Pfeiffer, Norbert;Pitz, Susanne
通讯作者：
Pitz, Susanne
影响因子：
1.6
作者：
Bicer, S;Fuller, GA;Hamlin, RL
通讯作者：
Hamlin, RL