ECG changes after rabbit coronavirus infection.
ECG changes after rabbit coronavirus infection.
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DOI：
10.1016/s0022-0736(99)90018-3
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发表时间：
1999-01
影响因子：
1.3
通讯作者：
Baric RS
中科院分区：
文献类型：
--
作者：
Alexander LK;Keene BW;Yount BL;Geratz JD;Small JD;Baric RS
本研究探讨了兔冠状病毒（RbCV）感染后的心电图（ECG）变化。我们已经表明，感染RbCV导致心肌炎和充血性心力衰竭的发展，一些RbCV感染的幸存者在慢性期继续发展为扩张型心肌病。对31只感染RbCV的家兔进行连续心电图记录。测量心率、P-R间期、QRS时限、QTc间期以及P波、QRS波和T波电压。记录还检查了传导、节律和复极的干扰。急性期和亚急性期的特征是窦性心动过速伴R波和T波电压降低以及传导、节律和复极紊乱。在慢性期的大多数动物中，随着QRS电压变化的消退，窦性心率恢复至接近基线值。RbCV感染期间观察到的ECG变化与人类心肌炎、心力衰竭和扩张型心肌病中观察到的间期/节段异常、心律紊乱、传导缺陷和心肌病理学谱相似。由于动物通常在急性期没有充血性心力衰竭的严重临床体征的情况下突然死亡，RbCV感染可能会增加心室脆弱性，导致心脏性猝死。RbCV感染可能为研究动物模型中的心脏性猝死提供了难得的机会，在该动物模型中，心室能够支持心室颤动，并且可以进行侵入性技术监测心脏功能。
This study examines the electrocardiographic (ECG) changes following rabbit coronavirus (RbCV) infection. We have shown that infection with RbCV results in the development of myocarditis and congestive heart failure and that some survivors of RbCV infection go on to develop dilated cardiomyopathy in the chronic phase. Serial ECGs were recorded on 31 RbCV-infected rabbits. Measurements of heart rate; P-R interval; QRS duration; QTc interval; and P-, QRS-, and T-wave voltages were taken. The recordings were also examined for disturbances of conduction, rhythm, and repolarization. The acute and subacute phases were characterized by sinus tachycardia with depressed R- and T-wave voltages as well as disturbances of conduction, rhythm, and repolarization. In most animals in the chronic phase, the sinus rate returned to near-baseline values with resolution of the QRS voltage changes. The ECG changes observed during RbCV infection are similar to the spectrum of interval/segment abnormalities, rhythm disturbances, conduction defects, and myocardial pathology seen in human myocarditis, heart failure, and dilated cardiomyopathy. Because animals often died suddenly in the absence of severe clinical signs of congestive heart failure during the acute phase, RbCV infection may increase ventricular vulnerability, resulting in sudden cardiac death. RbCV infection may provide a rare opportunity to study sudden cardiac death in an animal model in which the ventricle is capable of supporting ventricular fibrillation, and invasive techniques monitoring cardiac function can be performed.
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影响因子：
37.8
作者：
JAMES, TN;FROGGATT, P;NORTH, RL
通讯作者：
NORTH, RL
影响因子：
20.1
作者：
JAMES, TN
通讯作者：
JAMES, TN
影响因子：
6.4
作者：
EDWARDS, S;SMALL, JD;BARIC, RS
通讯作者：
BARIC, RS
DOI：
10.1016/0735-1097(92)90533-s
发表时间：
1992-03-15
影响因子：
24
作者：
GWATHMEY, JK;NAKAO, S;ABELMANN, WH
通讯作者：
ABELMANN, WH
影响因子：
37.8
作者：
ABELMANN, WH
通讯作者：
ABELMANN, WH