Neural systems for speech and song in autism.
Neural systems for speech and song in autism.
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DOI：
10.1093/brain/awr335
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Hirsch J
中科院分区：
文献类型：
--
作者：
Lai G;Pantazatos SP;Schneider H;Hirsch J
尽管自闭症患者有语言障碍，但音乐能力通常被保留下来。奇怪的是，与这些功能相关的大脑区域通常重叠，从而使研究自闭症中支持语言和歌曲的神经组织成为可能。在功能性磁共振和弥散张量成像期间，使用被动听觉刺激比较了低功能自闭症儿童和年龄匹配的对照儿童对语音和歌曲敏感的神经系统。在言语刺激期间，自闭症儿童的左额下回激活相对于对照组减少，但在歌曲刺激期间大于对照组。孤独症患者的左额下回和上级颞回之间的歌曲功能连接相对于语音功能也有所增加，大规模的连接显示了额-后连接的增加。虽然分数各向异性的左弓状束减少自闭症儿童相对于对照组，弓状束在额下回的结构终端是无法区分自闭症和对照组。分数各向异性与活动在左额下回语音和歌曲条件。总之，这些研究结果表明，在自闭症中，处理语音和歌曲的功能系统更有效地参与了歌曲比语音和预测与这些功能相关的结构途径是没有区别的控制。
Despite language disabilities in autism, music abilities are frequently preserved. Paradoxically, brain regions associated with these functions typically overlap, enabling investigation of neural organization supporting speech and song in autism. Neural systems sensitive to speech and song were compared in low-functioning autistic and age-matched control children using passive auditory stimulation during functional magnetic resonance and diffusion tensor imaging. Activation in left inferior frontal gyrus was reduced in autistic children relative to controls during speech stimulation, but was greater than controls during song stimulation. Functional connectivity for song relative to speech was also increased between left inferior frontal gyrus and superior temporal gyrus in autism, and large-scale connectivity showed increased frontal–posterior connections. Although fractional anisotropy of the left arcuate fasciculus was decreased in autistic children relative to controls, structural terminations of the arcuate fasciculus in inferior frontal gyrus were indistinguishable between autistic and control groups. Fractional anisotropy correlated with activity in left inferior frontal gyrus for both speech and song conditions. Together, these findings indicate that in autism, functional systems that process speech and song were more effectively engaged for song than for speech and projections of structural pathways associated with these functions were not distinguishable from controls.
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影响因子：
5.7
作者：
Fletcher, P. Thomas;Whitaker, Ross T.;Tao, Ran;DuBray, Molly B.;Froehlich, Alyson;Ravichandran, Caitlin;Alexander, Andrew L.;Bigler, Erin D.;Lange, Nicholas;Lainhart, Janet E.
通讯作者：
Lainhart, Janet E.
影响因子：
3.7
作者：
Gemma, Marco;de Vitis, Assunta;Beretta, Luigi
通讯作者：
Beretta, Luigi
DOI：
10.1111/j.1749-6632.2009.04853.x
发表时间：
2009-01-01
期刊：
NEUROSCIENCES AND MUSIC III: DISORDERS AND PLASTICITY
影响因子：
--
作者：
Boso, Marianna;Comelli, Mario;Politi, Pierluigi
通讯作者：
Politi, Pierluigi
影响因子：
5.7
作者：
Goodlett CB;Fletcher PT;Gilmore JH;Gerig G
通讯作者：
Gerig G
影响因子：
5.3
作者：
Belmonte, MK;Allen, G;Webb, SJ
通讯作者：
Webb, SJ