Chronic stress alters neural activity in medial prefrontal cortex during retrieval of extinction.
Chronic stress alters neural activity in medial prefrontal cortex during retrieval of extinction.
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DOI：
10.1016/j.neuroscience.2010.10.070
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发表时间：
2011-02-03
期刊：
影响因子：
3.3
通讯作者：
Wellman, C. L.
中科院分区：
文献类型：
--
作者：
Wilber, A. A.;Walker, A. G.;Southwood, C. J.;Farrell, M. R.;Lin, G. L.;Rebec, G. V.;Wellman, C. L.
关键词：
慢性束缚压力会导致内侧前额皮质发生形态变化，并破坏前额介导的行为，即消退恢复。为了评估这些变化的潜在生理相关性，我们比较了未应激大鼠和应激大鼠在恐惧调节和消退过程中边缘下和边缘前皮层的神经活动。将微丝束植入边缘下或边缘前皮层后，大鼠要么不受压力，要么通过放置在塑料限制器中而受压力（每天 3 小时，持续 1 周）。然后，大鼠经历恐惧调节和消退，同时记录边缘下或前边缘皮层神经元的活动。在训练的所有阶段评估冻结百分比和神经活动。慢性压力会增强获得条件性恐惧期间的冻结，并改变该阶段的前边缘和下边缘活动。在此阶段，压力不会改变最初的消退或条件刺激（CS）相关活动。然而，24小时后评估的应激损害了消退恢复，并且伴随着边缘前皮层和边缘下皮层神经元活动的改变。在前边缘皮质中，未受应激的大鼠对 CS 呈现的反应显示出活动减少，而应激的大鼠则没有表现出任何变化。在边缘下皮质中，未受应激的大鼠中的神经元表现出对 CS 的反应增加的放电，而应激大鼠在音调期间没有表现出边缘下的放电增加。最后，边缘下皮层而非边缘前皮层的 CS 相关放电与消退恢复相关。因此，应激引起的边缘下皮层神经元活动的改变可能是应激引起的消退恢复缺陷的原因。
Chronic restraint stress produces morphological changes in medial prefrontal cortex and disrupts a prefrontally mediated behavior, retrieval of extinction. To assess potential physiological correlates of these alterations, we compared neural activity in infralimbic and prelimbic cortex of unstressed versus stressed rats during fear conditioning and extinction. After implantation of microwire bundles into infralimbic or prelimbic cortex, rats were either unstressed or stressed via placement in a plastic restrainer (3 h/day for 1 week). Rats then underwent fear conditioning and extinction while activity of neurons in infralimbic or prelimbic cortex was recorded. Percent freezing and neural activity were assessed during all phases of training. Chronic stress enhanced freezing during acquisition of conditioned fear, and altered both prelimbic and infralimbic activity during this phase. Stress did not alter initial extinction or conditioned stimulus (CS)-related activity during this phase. However, stress impaired retrieval of extinction assessed 24 h later, and this was accompanied by alterations in neuronal activity in both prelimbic and infralimbic cortex. In prelimbic cortex, unstressed rats showed decreased activity in response to CS presentation, whereas stressed rats showed no change. In infralimbic cortex, neurons in unstressed rats exhibited increased firing in response to the CS, whereas stressed rats showed no increase in infralimbic firing during the tone. Finally, CS-related firing in infralimbic but not prelimbic cortex was correlated with extinction retrieval. Thus, the stress-induced alteration of neuronal activity in infralimbic cortex may be responsible for the stress-induced deficit in retrieval of extinction.
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DOI：
10.1038/npp.2008.123
发表时间：
2009-02
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.5
作者：
Homayoun, L;Jackson, ME;Moghaddam, B
通讯作者：
Moghaddam, B
影响因子：
2
作者：
Garcia, R;Chang, CH;Maren, S
通讯作者：
Maren, S
影响因子：
2
作者：
Farinelli, Missa;Deschaux, Olivier;Garcia, Rene
通讯作者：
Garcia, Rene
影响因子：
8.2
作者：
Holmes, Andrew;Wellman, Cara L.
通讯作者：
Wellman, Cara L.