At last: erythropoietin as a single glycoform.
At last: erythropoietin as a single glycoform.
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DOI:
10.1002/anie.201206090
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发表时间:
2012-11-12
影响因子:
16.6
通讯作者:
Danishefsky, Samuel J.
中科院分区:
文献类型:
--
作者:
Wang, Ping;Dong, Suwei;Brailsford, John A.;Iyer, Karthik;Townsend, Steven D.;Zhang, Qiang;Hendrickson, Ronald C.;Shieh, JaeHung;Moore, Malcolm A. S.;Danishefsky, Samuel J.
Given the central role of erythrocytes in enabling life, it is not surprising that there has evolved a highly sophisticated system for their production and orchestration. Broadly speaking, the multifaceted erythrocyte management process is encompassed in the term “erythropoiesis.”[1] In the early mammalian fetus, erythropoiesis begins in mesodermal cells in the yolk sac. With further development, the spleen and liver become the venues of erythrocyte production. Ultimately, the bone marrow becomes the “plant site” of erythropoiesis.[2]
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