SQSTM1/p62 and Hepatic Mallory-Denk Body Formation in Alcohol-Associated Liver Disease.
SQSTM1/p62 and Hepatic Mallory-Denk Body Formation in Alcohol-Associated Liver Disease.
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DOI：
10.1016/j.ajpath.2023.02.015
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发表时间：
2023-10
影响因子：
6
通讯作者：
Ding, Wen-Xing
中科院分区：
文献类型：
--
作者：
Qian, Hui;Ding, Wen-Xing
Sequestosome 1（SQSTM 1/p62;以下简称p62）是一种选择性自噬的自噬受体蛋白，主要是由于其与特异性定位于自噬体膜上的微管轻链3蛋白的直接相互作用。因此，受损的自噬导致p62的积累。p62也是许多人类肝脏疾病相关的细胞包涵体的常见组分，如Mallory-Denk小体、胞浆内透明小体、α1-抗胰蛋白酶聚集体以及p62小体和凝聚物。p62还充当细胞内信号传导枢纽，并且其涉及多种信号传导途径，包括核因子红细胞2相关因子2、NF-κB和雷帕霉素的机制靶点，其对于氧化应激、炎症、细胞存活、代谢和肝肿瘤发生至关重要。本文综述了p62在蛋白质质量控制中的最新研究进展，包括p62在p62应激颗粒和蛋白质聚集体的形成和降解中的作用，以及p62在酒精相关性肝病发病机制中对多种信号通路的调控。
Sequestosome 1 (SQSTM1/p62; hereafter p62) is an autophagy receptor protein for selective autophagy primarily due to its direct interaction with the microtubule light chain 3 protein that specifically localizes on autophagosome membranes. As a result, impaired autophagy leads to the accumulation of p62. p62 is also a common component of many human liver disease–related cellular inclusion bodies, such as Mallory-Denk bodies, intracytoplasmic hyaline bodies, α1-antitrypsin aggregates, as well as p62 bodies and condensates. p62 also acts as an intracellular signaling hub, and it involves multiple signaling pathways, including nuclear factor erythroid 2–related factor 2, NF-κB, and the mechanistic target of rapamycin, which are critical for oxidative stress, inflammation, cell survival, metabolism, and liver tumorigenesis. This review discusses the recent insights of p62 in protein quality control, including the role of p62 in the formation and degradation of p62 stress granules and protein aggregates as well as regulation of multiple signaling pathways in the pathogenesis of alcohol-associated liver disease.
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影响因子：
--
作者：
Cursio R;Colosetti P;Codogno P;Cuervo AM;Shen HM
通讯作者：
Shen HM
影响因子：
--
作者：
Bruha, R;Dvorak, K;Svestka, T
通讯作者：
Svestka, T
C9ORF72和P62的复合物使用精氨酸甲基化来消除自噬的应激颗粒。
影响因子：
16.6
作者：
Chitiprolu M;Jagow C;Tremblay V;Bondy-Chorney E;Paris G;Savard A;Palidwor G;Barry FA;Zinman L;Keith J;Rogaeva E;Robertson J;Lavallée-Adam M;Woulfe J;Couture JF;Côté J;Gibbings D
通讯作者：
Gibbings D
影响因子：
25.7
作者：
Chao X;Wang S;Fulte S;Ma X;Ahamed F;Cui W;Liu Z;Rülicke T;Zatloukal K;Zong WX;Liu W;Ni HM;Ding WX
通讯作者：
Ding WX
DOI：
10.1016/j.bbrc.2018.06.153
发表时间：
2018-09-18
影响因子：
3.1
作者：
Cabe M;Rademacher DJ;Karlsson AB;Cherukuri S;Bakowska JC
通讯作者：
Bakowska JC