Novel inductively coupled ear-bars (ICEs) to enhance restored fMRI signal from susceptibility compensation in rats.
Novel inductively coupled ear-bars (ICEs) to enhance restored fMRI signal from susceptibility compensation in rats.
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DOI：
10.1093/cercor/bhad479
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发表时间：
2024-01-14
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功能性磁共振成像在应用于啮齿类动物的脑深部区域（例如内嗅皮层）时面临固有的挑战，这是由于磁化率伪影引起的耳腔附近的信号损失以及与表面阵列线圈的长距离引起的灵敏度降低。鉴于脑深部区域在各种疾病中的关键作用，需要优化成像技术。为了减轻易磁化引起的信号损失，我们将婴儿乳霜引入中耳。为了提高脑深部区域的检测灵敏度，我们实施了感应耦合耳棒，导致内嗅皮层的灵敏度增加了约2倍。值得注意的是，感应耦合耳杆可以无缝地集成为附加设备，而不需要修改扫描仪接口。为了强调感应耦合耳杆的多功能性，我们在阿尔茨海默病大鼠模型中进行了基于回波规划成像的任务功能磁共振成像。作为概念的证明，我们还展示了静息状态功能磁共振成像连接地图，起源于左内嗅皮层-记忆和导航网络的中心枢纽-杏仁核海马区，岛叶皮层，杏仁核系统，扣带皮层，次级视觉皮层和运动皮层。这项工作展示了一种优化的程序，用于通过传统的磁共振成像探测器获取从先前具有挑战性的种子区域发出的大规模网络，从而有助于改善对功能性磁共振成像结果的观察。
Functional magnetic resonance imaging faces inherent challenges when applied to deep-brain areas in rodents, e.g. entorhinal cortex, due to the signal loss near the ear cavities induced by susceptibility artifacts and reduced sensitivity induced by the long distance from the surface array coil. Given the pivotal roles of deep brain regions in various diseases, optimized imaging techniques are needed. To mitigate susceptibility-induced signal losses, we introduced baby cream into the middle ear. To enhance the detection sensitivity of deep brain regions, we implemented inductively coupled ear-bars, resulting in approximately a 2-fold increase in sensitivity in entorhinal cortex. Notably, the inductively coupled ear-bar can be seamlessly integrated as an add-on device, without necessitating modifications to the scanner interface. To underscore the versatility of inductively coupled ear-bars, we conducted echo-planner imaging-based task functional magnetic resonance imaging in rats modeling Alzheimer’s disease. As a proof of concept, we also demonstrated resting-state-functional magnetic resonance imaging connectivity maps originating from the left entorhinal cortex—a central hub for memory and navigation networks-to amygdala hippocampal area, Insular Cortex, Prelimbic Systems, Cingulate Cortex, Secondary Visual Cortex, and Motor Cortex. This work demonstrates an optimized procedure for acquiring large-scale networks emanating from a previously challenging seed region by conventional magnetic resonance imaging detectors, thereby facilitating improved observation of functional magnetic resonance imaging outcomes.
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DOI：
10.1016/j.bpsc.2018.12.002
发表时间：
2019-06-01
影响因子：
5.9
作者：
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发表时间：
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影响因子：
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影响因子：
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影响因子：
5.7
作者：
Griffanti L;Salimi-Khorshidi G;Beckmann CF;Auerbach EJ;Douaud G;Sexton CE;Zsoldos E;Ebmeier KP;Filippini N;Mackay CE;Moeller S;Xu J;Yacoub E;Baselli G;Ugurbil K;Miller KL;Smith SM
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