Deciphering the role of microRNAs in mustard gas-induced toxicity.
Deciphering the role of microRNAs in mustard gas-induced toxicity.
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DOI：
10.1111/nyas.14539
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发表时间：
2021-05
影响因子：
5.2
通讯作者：
Agarwal R
中科院分区：
文献类型：
--
作者：
Mishra N;Raina K;Agarwal R
芥子气（硫芥子气，SM）是一种高度起泡的化学战剂，于1917年首次在战争中使用，最近在两伊战争（20世纪80年代）和叙利亚冲突（21世纪初）中使用;然而，库存和旧炮弹暴露的威胁仍然很大。尽管SM诱导毒性的研究已经进行了很长时间，但描绘精确的分子途径仍然是一个正在进行的研究领域;因此，尝试新的方法来破译这些机制并开发与SM诱导毒性相关的详细途径网络是很重要的。其中一个途径是探索microRNAs（miRNAs）在SM诱导的毒性中的作用。最近关于miRNAs调控作用的研究为填补SM毒性相关机制的空白提供了重要的结果。此外，差异表达的miRNA也可用作诊断标记物，以确定暴露个体的毒性程度。因此，在我们的综述中，我们总结了迄今为止在细胞和动物模型中进行的研究，包括人类受试者，在SM和/或SM类似物诱导的毒性中miRNA的表达谱和作用。这一领域的进一步详细研究将指导我们制定预防策略，诊断工具和治疗干预措施，以对抗SM诱导的毒性。
Mustard gas (sulfur mustard, SM), a highly vesicating chemical warfare agent, was first deployed in warfare in 1917 and recently during the Iraq–Iran war (1980s) and Syrian conflicts (2000s); however, the threat of exposure from stockpiles and old artillery shells still looms large. Whereas research has been long ongoing on SM-induced toxicity, delineating the precise molecular pathways is still an ongoing area of investigation; thus, it is important to attempt novel approaches to decipher these mechanisms and develop a detailed network of pathways associated with SM-induced toxicity. One such avenue is exploring the role of microRNAs (miRNAs) in SM-induced toxicity. Recent research on the regulatory role of miRNAs provides important results to fill in the gaps in SM toxicity–associated mechanisms. In addition, differentially expressed miRNAs can also be used as diagnostic markers to determine the extent of toxicity in exposed individuals. Thus, in our review, we have summarized the studies conducted so far in cellular and animal models, including human subjects, on the expression profiles and roles of miRNAs in SM- and/or SM analog–induced toxicity. Further detailed research in this area will guide us in devising preventive strategies, diagnostic tools, and therapeutic interventions against SM-induced toxicity.
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